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. 2023 Nov 22;186(24):5201-5202.
doi: 10.1016/j.cell.2023.10.027.

Staphylococcus scratches its itch

Jack Major  1 , Shruti Naik  2
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Free article

Staphylococcus scratches its itch

Jack Major et al. Cell. .
Free article

Abstract

Itch exacerbates infection and inflammation-associated skin pathology. In this issue of Cell, Deng et al. identify a V8 protease released by Staphylococcus aureus triggering itch via neuronal protease-activated receptor 1. In so doing, they uncover profound consequences of microbial neurosensory modulation and the ensuing scratch-induced tissue damage that potentiates infection.

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Conflict of interest statement

Declaration of interests S.N. is on the SAB of Seed Inc. and receives funding from Takeda Pharmaceuticals.

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