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. 2024 Apr;26(4):1001-1011.
doi: 10.1007/s12094-023-03340-0. Epub 2023 Nov 24.

Nomogram for predicting overall survival after curative gastrectomy using inflammatory, nutritional and pathological factors

Qi Wang  1 , Qiang Zhang  2 , Jiankang Zhu  3 , Linchuan Li  3 , Runzhi Zeng  4 , Huanxin Ding  4 , Zhenmin Li  1 , Tianyi Feng  4 , Ruiqi Hao  1 , Guangyong Zhang  5
Affiliations

Nomogram for predicting overall survival after curative gastrectomy using inflammatory, nutritional and pathological factors

Qi Wang et al. Clin Transl Oncol. 2024 Apr.

Abstract

Purpose: To establish a nomogram for predicting the overall survival (OS) in patients with gastric cancer (GC) based on inflammatory, nutritional and pathological factors.

Methods: GC patients underwent curative gastrectomy from January 2012 to June 2017 in our hospital were included, and were classified into training set and validation set with a ratio of 7:3. Then variables associated with OS were analyzed using univariate and multivariate Cox regression analysis. Nomograms predicting OS were built using variables from multivariable Cox models. Finally, Kaplan-Meier curve and Log-rank test were also conducted to analyze the 1-yr, 3-yr and 5-yr OS to validate the efficiency of risk stratification of the nomogram.

Results: A total of 366 GC patients were included. After univariate and multivariate Cox regression analysis, age (HR = 1.52, 95% CI = 1.01-2.30, P = 0.044), CA50 (HR = 1.90, 95% CI = 1.12-3.21, P = 0.017), PNI (HR = 1.65, 95% CI = 1.13-2.39, P = 0.009), SII (HR = 1.46, 95% CI = 1.03-2.08, P = 0.036), T stage (HR = 2.26, 95% CI = 1.01-5.05, P = 0.048; HR = 7.24, 95% CI = 3.64-14.40, P < 0.001) were independent influencing factors on the survival time of GC patients. Five factors including CEA, prognostic nutritional index (PNI), systemic immune-inflammation index (SII), ln (tumor size), T stage, and N stage were identified and entered the nomogram, which showed good discrimination and calibration in both sets. On internal validation, 1-yr, 3-yr and 5-yr nomogram demonstrated a good discrimination with an area under the ROC curve (AUC) of 0.77, 0.84 and 0.86, respectively. The AUC for 1-yr, 3-yr and 5-yr nomogram in validation set was 0.77, 0.79 and 0.81, respectively. The OS in low risk group of training cohort and validation cohort was significantly higher than that of intermediate risk group and high risk group, respectively.

Conclusions: We established a nomogram based on PNI, SII and pathological factors for predicting OS in GC patients. In addition, its efficiency was validated by validation set and stratified analysis.

Keywords: Cox regression analysis; Gastric cancer; Nomogram; Overall survival; Prognosis.

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References

    1. Machlowska J, Baj J, Sitarz M, Maciejewski R, Sitarz R. Gastric cancer: epidemiology, risk factors, classification, genomic characteristics and treatment strategies. Int J Mol Sci. 2020;21(11):4012. https://doi.org/10.3390/ijms21114012 . - DOI - PubMed - PMC
    1. Quéro L, Guillerm S, Hennequin C. Neoadjuvant or adjuvant therapy for gastric cancer. World J Gastrointest Oncol. 2015;7(8):102–10. https://doi.org/10.4251/wjgo.v7.i8.102 . - DOI - PubMed - PMC
    1. Sung JJ, Ng EK, Lin JT, Ho KY, Ji JF, Sugano K, et al. Digestive cancer management in Asia: position statements: a report on GI Oncology Summit in 2011. J Gastroenterol Hepatol. 2012;27(9):1417–22. https://doi.org/10.1111/j.1440-1746.2012.07194.x . - DOI - PubMed
    1. Piazza C, Bresciani L, Giannini L. Depth of invasion for prognostic stratification in oral cavity cancer: do we need further validation? Ann Transl Med. 2019;7(Suppl 3):S84. https://doi.org/10.21037/atm.2019.04.19 . - DOI - PubMed - PMC
    1. Howaldt HP, Kainz M, Euler B, Vorast H, DOSAK. Proposal for modification of the TNM staging classification for cancer of the oral cavity. J Craniomaxillofac Surg. 1999;27(5):275–88. https://doi.org/10.1054/jcms.1999.0070 . - DOI - PubMed

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