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. 2023 Nov 24;7(1):25.
doi: 10.1186/s41824-023-00185-2.

[18F]PSMA-1007 PET is comparable to [99mTc]Tc-DMSA SPECT for renal cortical imaging

Kristian Valind  1   2   3 , David Minarik  4   5   6 , Sabine Garpered  7 , Eva Persson  8 , Jonas Jögi  4   5   8   7 , Elin Trägårdh  4   5   7
Affiliations

[18F]PSMA-1007 PET is comparable to [99mTc]Tc-DMSA SPECT for renal cortical imaging

Kristian Valind et al. Eur J Hybrid Imaging. .

Abstract

Background: Scintigraphy using technetium-99m labelled dimercaptosuccinic acid ([99mTc]Tc-DMSA), taken up in the proximal tubules, is the standard in functional imaging of the renal cortex. Recent guidelines recommend performing [99mTc]Tc-DMSA scintigraphy with single photon emission computed tomography (SPECT). Prostate-specific membrane antigen (PSMA) targeted positron emission tomography (PET) is used for staging and localization of recurrence in prostate cancer. A high renal uptake is often seen on PSMA PET, concordant with known PSMA expression in proximal tubules. This suggests PSMA PET could be used analogous to [99mTc]Tc-DMSA scintigraphy for renal cortical imaging. [18F]PSMA-1007 is a promising radiopharmaceutical for this purpose due to low urinary clearance. In this study, we aimed to compare [18F]PSMA-1007 PET to [99mTc]Tc-DMSA SPECT regarding split renal uptake and presence of renal uptake defects, in patients with prostate cancer. Three readers interpreted PET and SPECT images regarding presence of renal uptake defects, with each kidney split into cranial, mid and caudal segments. Kidneys were segmented in PET and SPECT images, and left renal uptake as a percentage of total renal uptake was measured.

Results: Twenty patients with prostate cancer were included. 2 participants had single kidneys; thus 38 kidneys were evaluated. A total of 29 defects were found on both [99mTc]Tc-DMSA SPECT and [18F]PSMA-1007 PET. Cohen's kappa for concordance regarding presence of any defect was 0.76 on a per-segment basis and 0.67 on a per-kidney basis. Spearman's r for left renal uptake percentage between [99mTc]Tc-DMSA SPECT and [18F]PSMA-1007 PET was 0.95.

Conclusions: [18F]PSMA-1007 PET is comparable to [99mTc]Tc-DMSA SPECT for detection of uptake defects in this setting. Measurements of split renal function made using [18F]PSMA-1007 PET are valid and strongly correlated to measurements made with [99mTc]Tc-DMSA SPECT.

Keywords: DMSA; PET; PSMA; Renal cortex; Renal function; SPECT.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Total number of defects found per modality, final consensus interpretations. SPECT single photon emission computed tomography; PET positron emission tomography
Fig. 2
Fig. 2
Example PET and SPECT images from two patients. Solid arrows in a indicate a defect found by readers on both PET and SPECT. Dotted arrows in a indicate a defect found on PET but not on SPECT. Dashed arrows in b indicate a defect readers found on SPECT but not on PET images. SPECT: single photon emission computed tomography; PET: positron emission tomography
Fig. 3
Fig. 3
Correlation (a) and Bland–Altman (b) plots of left renal uptake percentage (LRU%) measured with SPECT and PET. Dashed lines indicate mean difference and 95% limits of agreement (mean ± 1.96 SD). SPECT: single photon emission computed tomography; PET: positron emission tomography; LRU%, left renal uptake percentage; SD, standard deviation
See this image and copyright information in PMC

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