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Review
. 2023 Nov 24;23(1):258.
doi: 10.1186/s12902-023-01496-y.

Primary adrenal diffuse large B cell Lymphoma with Tumor thrombus in central adrenal vein: a case report and literature review

Qingfei Xing  1 , Chunhai Hu  1 , Qingqing Zhao  2 , Chunling Zhang  3 , Tingshuai Cao  1 , Xinghua Gao  1 , Li He  4 , Feng Guo  5
Affiliations
Review

Primary adrenal diffuse large B cell Lymphoma with Tumor thrombus in central adrenal vein: a case report and literature review

Qingfei Xing et al. BMC Endocr Disord. .

Abstract

Primary adrenal lymphoma (PAL) is a rare disease confined wholly or chiefly to extramural involvement. Tumor thrombus in the central adrenal vein, renal vein, and inferior vena cava has been reported in adrenal pheochromocytoma, adrenocortical carcinoma, adrenal metastasis carcinoma, and adrenal leiomyosarcoma. Primary adrenal diffuse large B cell lymphoma with tumor thrombus in the central adrenal vein has rarely been reported in the current study. ( We searched in PubMed, Web of Science databases, Embase, and Medline in the English language from 1970 to December 2022. The keywords used were "Primary adrenal lymphoma " and " tumor thrombus".) CASE PRESENTATION: In this report, we discuss the case of a 57-year-old woman who complained of abdominal discomfort following cold stimulation, low back pain, anorexia, fatigue, and weight loss for 1 year. Contrast-enhanced spiral computed tomography (CT) showed mild-to-moderate enhancement of the bilateral masses and central adrenal vein tumor thrombus. After an exhaustive study, the patient was diagnosed with primary adrenal diffuse large B-cell lymphoma. In the diagnosis of PAL, the possibility of a tumor embolism in the central adrenal vein, renal vein, or inferior vena cava should be considered, although this is rare.

Keywords: Cadrenal vein; Case report; Diffuse large B-cell Lymphoma(DLBCL); Primary adrenal Lymphoma (PAL); Tumor thrombus.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
(A, B) Contrast-enhanced spiral computed tomography (CT) showed mild to moderate enhancement of bilateral masses and central adrenal vein tumor thrombus(arrow)
Fig. 2
Fig. 2
(A, B)Contrast-enhanced MR confirmed a long T1 and T2 signal shadow (arrow). Contrast-enhanced MRI revealed moderate enhancement in adrenal masses (C,arrow) and tumor thrombus in the central adrenal vein (D,arrow) and left renal vein (E,arrow)
Fig. 3
Fig. 3
(A) Hematoxylin and eosin staining showed nuclear pleomorphism. (B) Immunohistochemical staining for the B-cell marker CD20 was positive
Fig. 4
Fig. 4
CT revealed liver(A,arrow) and retroperitoneal lymph node metastases(B,arrow)
See this image and copyright information in PMC

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