Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2023 Nov 23;23(1):467.
doi: 10.1186/s12890-023-02757-1.

Progression of obstructive sleep apnoea after renal denervation is not associated with hypertension exaggeration

Lyudmila S Korostovtseva  1 , Mikhail V Ionov  2 , Elizaveta A Shcherbakova  2 , Mikhail V Bochkarev  2 , Igor V Emelyanov  2 , Yulia S Yudina  2 , Svetlana A Mironova  2 , Dmitry A Zverev  2 , Dmitry S Lebedev  2 , Aleksandr D Vakhrushev  2 , Natalia G Avdonina  2 , Nadezhda E Zvartau  2 , Evgeny N Mikhaylov  2 , Yurii V Sviryaev  2 , Aleksandra O Konradi  2
Affiliations
Clinical Trial

Progression of obstructive sleep apnoea after renal denervation is not associated with hypertension exaggeration

Lyudmila S Korostovtseva et al. BMC Pulm Med. .

Abstract

Purpose: In a cohort, observational prospective trial, we assessed the long-term dynamics of sleep-disordered breathing in patients with resistant hypertension after renal denervation and their association with blood pressure change at remote follow-up.

Materials and methods: Twenty-eight patients with stable hypertension who were recruited for endovascular radiofrequency renal denervation in 2012-2019 and had valid both baseline and follow-up sleep study, were included in the analysis. All patients underwent physical examination, anthropometry, office and ambulatory blood pressure measurements, blood and urine tests, kidney visualization, and full polysomnography before and within 12-36 months after renal denervation.

Results: The average follow-up comprised 30.1 ± 8.4 months. At long-term follow-up, no significant changes in creatinine level, estimated glomerular filtration rate, body mass index were registered. There was a significant increase in sleep apnea severity indices: the mean change in apnea-hypopnea index comprised 9.0(-21.1;25.2) episodes/h, in oxygen desaturation index 6.5(-16.8;35.9) episodes/h, in the average SpO2 -1.7(-5.6;1.9)%. Over 12-month follow-up, there were no significant differences in blood pressure response in patients with and without sleep apnea. The baseline apnea-hypopnea and oxygen desaturation indices and the mean SpO2 were associated with the circadian blood pressure profile at follow-up, but did not correlate with the blood pressure response.

Conclusions: Although the severity of sleep apnea worsens at > 12 months follow-up after renal denervation, this is not associated with hypertension exaggeration.

Keywords: Apnea-hypopnea index; Obstructive sleep apnea; Renal denervation; Resistant hypertension; Sympathetic nervous system.

PubMed Disclaimer

Conflict of interest statement

LS, MI, ES, MB, IE, YY, SM, DZ, DL, AV, NA, NZ, EM, YS, AK: no conflict of interest.

Figures

Fig. 1
Fig. 1
Study flow chart
Fig. 2
Fig. 2
Changes in the indices of obstructive sleep apnea severity and body mass index
See this image and copyright information in PMC

References

    1. American Academy of Sleep Medicine . International classification of sleep disorders. 3. Darien, IL: American Academy of Sleep Medicine; 2014.
    1. Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH guidelines for the management of arterial Hypertension. Eur Heart journalю. 2018;39(33):3021–104. doi: 10.1093/eurheartj/ehy339. - DOI - PubMed
    1. Pedrosa RP, Drager LF, Gonzaga CC, et al. Obstructive sleep apnea: the most common secondary cause of Hypertension associated with resistant Hypertension. Hypertension. 2011;58(5):811–7. doi: 10.1161/HYPERTENSIONAHA.111.179788. - DOI - PubMed
    1. Narkiewicz K, Somers VK. The sympathetic nervous system and obstructive sleep apnea: implications for Hypertension. J Hypertens. 1997;15(12Pt2):1613–9. doi: 10.1097/00004872-199715120-00062. - DOI - PubMed
    1. Parati G, Lombardi C, Hedner J, et al. Recommendations for the management of patients with obstructive sleep apnoea and Hypertension. Eur Resp J. 2013;41(3):523–38. doi: 10.1183/09031936.00226711. - DOI - PubMed