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Review
. 2023 Oct 31;12(11):1389.
doi: 10.3390/biology12111389.

Telomere Dynamics in Livestock

Nan Zhang  1 , Emilie C Baker  2 , Thomas H Welsh Jr  1   3 , David G Riley  1   3
Affiliations
Review

Telomere Dynamics in Livestock

Nan Zhang et al. Biology (Basel). .

Abstract

Telomeres are repeated sequences of nucleotides at the end of chromosomes. They deteriorate across mitotic divisions of a cell. In Homo sapiens this process of lifetime reduction has been shown to correspond with aspects of organismal aging and exposure to stress or other insults. The early impetus to characterize telomere dynamics in livestock related to the concern that aged donor DNA would result in earlier cell senescence and overall aging in cloned animals. Telomere length investigations in dairy cows included breed effects, estimates of additive genetic control (heritability 0.12 to 0.46), and effects of external stressors on telomere degradation across animal life. Evaluation of telomeres with respect to aging has also been conducted in pigs and horses, and there are fewer reports of telomere biology in beef cattle, sheep, and goats. There were minimal associations of telomere length with animal productivity measures. Most, but not all, work in livestock has documented an inverse relationship between peripheral blood cell telomere length and age; that is, a longer telomere length was associated with younger age. Because livestock longevity affects productivity and profitability, the role of tissue-specific telomere attrition in aging may present alternative improvement strategies for genetic improvement while also providing translational biomedical knowledge.

Keywords: cattle; goats; horses; livestock; longevity; pigs; sheep; telomere.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Louzon M., Coeurdassier M., Gimbert F., Pauget B., de Vaufleury A. Telomere dynamic in humans and animals: Review and perspectives in environmental toxicology. Environ. Int. 2019;131:105025. doi: 10.1016/j.envint.2019.105025. - DOI - PubMed
    1. Shay J.W., Wright W.E. Telomeres and telomerase: Three decades of progress. Nat. Rev. Genet. 2019;20:299–309. doi: 10.1038/s41576-019-0099-1. - DOI - PubMed
    1. Srinivas N., Rachakonda S., Kumar R. Telomeres and telomere length: A general overview. Cancers. 2020;12:558. doi: 10.3390/cancers12030558. - DOI - PMC - PubMed
    1. Vaiserman A., Krasnienkov D. Telomere length as a marker of biological age: State-of-the-art, open issues, and future perspectives. Front. Genet. 2020;11:630186. doi: 10.3389/fgene.2020.630186. - DOI - PMC - PubMed
    1. Moyzis R.K., Buckingham J.M., Cram L.S., Dani M., Deaven L.L., Jones M.D., Meyne J., Ratliff R.L., Wu J.R. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc. Natl. Acad. Sci. USA. 1988;85:6622–6626. doi: 10.1073/pnas.85.18.6622. - DOI - PMC - PubMed

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