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. 2023 Oct 28;21(11):566.
doi: 10.3390/md21110566.

The Polyketides with Antimicrobial Activities from a Mangrove Endophytic Fungus Trichoderma lentiforme ML-P8-2

Yihao Yin  1 , Qi Tan  1 , Jianying Wu  1 , Tao Chen  1 , Wencong Yang  1 , Zhigang She  1 , Bo Wang  1
Affiliations

The Polyketides with Antimicrobial Activities from a Mangrove Endophytic Fungus Trichoderma lentiforme ML-P8-2

Yihao Yin et al. Mar Drugs. .

Abstract

Five new polyketides, including two chromones (1-2), two phenyl derivatives (4-5), and a tandyukusin derivative (6), along with five known polyketides (3 and 7-10) were isolated from mangrove endophytic fungus Trichoderma lentiforme ML-P8-2. The planar structures of compounds were elucidated via detailed 1D, 2D NMR, and HR-ESI-MS analysis. ECD spectra, optical rotation values calculation, and alkali hydrolysis were applied in the determination of the absolute configuration of the new compounds. In bioassays, 6 and 9 exhibited promising antifungal activities against Penicillium italicum, with an MIC value of 6.25 μM for both compounds. Moreover, 3 displayed moderate AChE inhibitory activity with an IC50 value of 20.6 ± 0.3 μM.

Keywords: AChE inhibitory activity; Trichoderma lentiforme; antimicrobial activity; mangrove endophytic fungus; polyketide.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structures of compounds 1–10.
Figure 2
Figure 2
Two-dimensional NMR correlation signals of new compounds 1, 2, 4–6.
Figure 3
Figure 3
(i) Experimental and calculated ECD spectra of 1; (ii) experimental and calculated ECD spectra of 5.
Figure 4
Figure 4
(i) alkali-hydrolysis reactions of compounds 6 and 8; (ii) key NOESY correlation signals of 6.
See this image and copyright information in PMC

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