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Review
. 2025 Apr;16(2):512-534.
doi: 10.1007/s12975-023-01216-7. Epub 2023 Nov 25.

Current Status and Progress in Stem Cell Therapy for Intracerebral Hemorrhage

Ning Ding  1   2 , Ran Luo  1   2 , Qian Zhang  2 , Huanhuan Li  1   2 , Shuixian Zhang  1 , Huanran Chen  1 , Rong Hu  3
Affiliations
Review

Current Status and Progress in Stem Cell Therapy for Intracerebral Hemorrhage

Ning Ding et al. Transl Stroke Res. 2025 Apr.

Abstract

Intracerebral hemorrhage is a highly prevalent and prognostically poor disease, imposing immeasurable harm on human life and health. However, the treatment options for intracerebral hemorrhage are severely limited, particularly in terms of improving the microenvironment of the lesion, promoting neuronal cell survival, and enhancing neural function. This review comprehensively discussed the application of stem cell therapy for intracerebral hemorrhage, providing a systematic summary of its developmental history, types of transplants, transplantation routes, and transplantation timing. Moreover, this review presented the latest research progress in enhancing the efficacy of stem cell transplantation, including pretransplantation preconditioning, genetic modification, combined therapy, and other diverse strategies. Furthermore, this review pioneeringly elaborated on the barriers to clinical translation for stem cell therapy. These discussions were of significant importance for promoting stem cell therapy for intracerebral hemorrhage, facilitating its clinical translation, and improving patient prognosis.

Keywords: Intracerebral hemorrhage; Neurological function; Stem cell therapy; Translational medicine.

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Conflict of interest statement

Declarations. Ethics Approval and Consent to Participate: This review had no risk in ethics approval and consent to participate. All information was obtained from publicly available articles. Consent for Publication: All authors approved the final manuscript and the submission to this journal. Conflict of Interest: The authors declare no competing interests.

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