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Meta-Analysis
. 2023 Nov 24;23(1):1143.
doi: 10.1186/s12885-023-11657-w.

Oxidative balance score and risk of cancer: a systematic review and meta-analysis of observational studies

Motahareh Hasani  1 , Seyedeh Parisa Alinia  2 , Maryam Khazdouz  3 , Sahar Sobhani  4 , Parham Mardi  4 , Hanieh-Sadat Ejtahed  5   6 , Mostafa Qorbani  7   8
Affiliations
Meta-Analysis

Oxidative balance score and risk of cancer: a systematic review and meta-analysis of observational studies

Motahareh Hasani et al. BMC Cancer. .

Abstract

Background: The oxidative balance score (OBS) has been utilized to assess the overall pro- and antioxidant exposure status in various chronic diseases. The current meta-analysis was carried out to pool the association between OBS and the risk of cancer.

Methods: We systematically searched the Web of Science, PubMed, Scopus, Embase, and Google Scholar up to August 2023. All observational studies which evaluated the association of OBS with the risk of cancers were included. There was no time of publication or language restrictions. Heterogeneity between studies was assessed using the Chi-square-based Q-test and the I2. A random-effects model meta-analysis was conducted to estimate the pooled effect sizes. Possible sources of heterogeneity were explored by subgroup and meta-regression analysis.

Results: Totally, 15 studies (9 case-control and 6 cohorts) were eligible for meta-analysis. Random effect model meta-analysis of case-control studies showed that higher OBS significantly decreases the odds of cancers (pooled OR: 0.64, 95% CI: 0.54, 0.74). In the cohort studies, the association of OBS with the risk of cancers was not significant (pooled HR: 0.97, 95% CI: 0.80,1.18). The subgroup analysis showed that cancer type and gender were the potential sources of heterogeneity.

Conclusion: Our results show an inverse and significant association between higher OBS and odds of colorectal cancers in case-control and cohort studies. In the case of prostate cancer in cohort studies, our results did not align with the hypothesis. Considering the importance of diet and antioxidant balance in the conditions of malignancy, it is suggested to conduct more comprehensive studies with standard measurement methods to obtain conclusive results.

Keywords: Cancer; Malignancy; Neoplasms; Oxidative balance score.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram of the number of studies selected into the meta-analysis
Fig. 2
Fig. 2
Forest plot of association between OBS and risk of cancers in case–control studies
Fig. 3
Fig. 3
Sensitivity analysis: meta-analysis of random-effects estimates with studies omitted in case-controls
Fig. 4
Fig. 4
Funnel plot detailing publication bias in the case–control studies reporting the association between OBS and risk of cancers
Fig. 5
Fig. 5
Forest plot of association between OBS and risk of cancers in cohort studies
Fig. 6
Fig. 6
Sensitivity analysis: meta-analysis of random-effects estimates with studies omitted in cohorts
Fig. 7
Fig. 7
Funnel plot detailing publication bias in the cohort studies reporting the association between OBS and risk of cancers
See this image and copyright information in PMC

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