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Review
. 2023 Nov 9;11(11):3006.
doi: 10.3390/biomedicines11113006.

The Role of Perivascular Adipose Tissue in the Pathogenesis of Endothelial Dysfunction in Cardiovascular Diseases and Type 2 Diabetes Mellitus

Alessia Valentini  1 , Carmine Cardillo  2   3 , David Della Morte  1 , Manfredi Tesauro  1
Affiliations
Review

The Role of Perivascular Adipose Tissue in the Pathogenesis of Endothelial Dysfunction in Cardiovascular Diseases and Type 2 Diabetes Mellitus

Alessia Valentini et al. Biomedicines. .

Abstract

Cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM) are two of the four major chronic non-communicable diseases (NCDs) representing the leading cause of death worldwide. Several studies demonstrate that endothelial dysfunction (ED) plays a central role in the pathogenesis of these chronic diseases. Although it is well known that systemic chronic inflammation and oxidative stress are primarily involved in the development of ED, recent studies have shown that perivascular adipose tissue (PVAT) is implicated in its pathogenesis, also contributing to the progression of atherosclerosis and to insulin resistance (IR). In this review, we describe the relationship between PVAT and ED, and we also analyse the role of PVAT in the pathogenesis of CVDs and T2DM, further assessing its potential therapeutic target with the aim of restoring normal ED and reducing global cardiovascular risk.

Keywords: cardiovascular diseases (CVDs); endothelial dysfunction (ED); insulin resistance (IR); non-communicable diseases (NCDs); perivascular adipose tissue (PVAT); type 2 diabetes mellitus (T2DM).

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PVAT-derived bioactive molecules.
Figure 2
Figure 2
PVAT-derived adipokines and cytokines.
Figure 3
Figure 3
The relationship between dysfunctional PVAT, cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM).
See this image and copyright information in PMC

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References

    1. Budreviciute A., Damiati S. Management and prevention strategies for non-communicable diseases (NCDs) and their risk factors. Front. Public Health. 2020;8:574111. doi: 10.3389/fpubh.2020.574111. - DOI - PMC - PubMed
    1. Huijts T., Stornes P. Prevalence of physical and mental non-communicable diseases in Europe: Findings from the European Social Survey (2014) special module on the social determinants of health. Eur. J. Public Health. 2017;27((Suppl. S1)):8–13. doi: 10.1093/eurpub/ckw232. - DOI - PubMed
    1. World Health Organization Noncommunicable Diseases (NCD) 2019. [(accessed on 29 June 2023)]. Available online: https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases.
    1. World Health Organization . Noncommunicable Diseases Country Profiles 2018. World Health Organization; Geneva, Switzerland: 2018.
    1. WHO Regional Office for Europe . Monitoring Noncommunicable Disease Commitments in Europe 2021: Are We on Track to Reach Targets 10 Years after the Moscow Declaration and First United Nations High-Level Meeting? WHO Regional Office for Europe; Copenhagen, Denmark: 2021.

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