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Review
. 2023 Nov 14;13(11):1652.
doi: 10.3390/biom13111652.

Intracranial Aneurysms and Lipid Metabolism Disorders: From Molecular Mechanisms to Clinical Implications

Tonglin Pan  1   2 , Yuan Shi  1   2 , Guo Yu  1   2 , Abdureshid Mamtimin  1   2 , Wei Zhu  1   2
Affiliations
Review

Intracranial Aneurysms and Lipid Metabolism Disorders: From Molecular Mechanisms to Clinical Implications

Tonglin Pan et al. Biomolecules. .

Abstract

Many vascular diseases are linked to lipid metabolism disorders, which cause lipid accumulation and peroxidation in the vascular wall. These processes lead to degenerative changes in the vessel, such as phenotypic transformation of smooth muscle cells and dysfunction and apoptosis of endothelial cells. In intracranial aneurysms, the coexistence of lipid plaques is often observed, indicating localized lipid metabolism disorders. These disorders may impair the function of the vascular wall or result from it. We summarize the literature on the relationship between lipid metabolism disorders and intracranial aneurysms below.

Keywords: intracranial aneurysm; lipid metabolism disorder; statin; subarachnoid hemorrhage.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Intracranial aneurysms are influenced by LMD at different stages of their development and rupture (a–d).
See this image and copyright information in PMC

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