Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Nov 1;10(11):1272.
doi: 10.3390/bioengineering10111272.

Fabrication of a Reflective Optical Imaging Device for Early Detection of Breast Cancer

Huu Thuan Mai  1 , Duc Quan Ngo  1 , Hong Phuong Thi Nguyen  2 , Duong Duc La  3
Affiliations

Fabrication of a Reflective Optical Imaging Device for Early Detection of Breast Cancer

Huu Thuan Mai et al. Bioengineering (Basel). .

Abstract

This work presented the design and fabrication of a blood vessel and breast tumor detection device (BKA-06) based on optical energy spectroscopy. The BKA-06 device uses red-to-near-infrared light-emitting diodes that allow physicians or physicians to visualize blood vessels and surface structures such as breast tumors with the naked eye. The device consists of a built-in current control circuit to have the appropriate brightness (maximum illuminance of 98,592 lux) for the examination of superficial tumors deep under the skin, with a scan time of 3-5 min. The device BKA-06 can facilely observe each layer of blood vessels at the depth of the skin. For breast tumors, the location, size, and invasive areas around the tumor can also be visualized with the naked eye using the BKA-06 sensor. The results show that the BKA-06 sensor can provide clear breast tumor and vascular images, with a penetration of up to 15 cm in the skin and tissue layers of the breast. The breast tumor scanning tests with the BKA-06 sensor gave patients quick results and compared them through cell biopsy and MRI, respectively. The device has the advantages of being simple and easy to use, providing potential practical applications in the medical field and reducing costs for patients when taking MRI or CT scans. Therefore, the BKA-06 device is expected to help doctors and medical staff overcome difficulties in infusion, as well as identify breast tumors to support early breast cancer diagnosis and treatment.

Keywords: BKA-06; blood vessels detection device; medicine; red LED lights.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical formular and structure of isoleucine and hemoglobin—the nucleus of red blood cells.
Figure 2
Figure 2
Current stabilizer circuit for LED and sensor (the red line is the positive wire, the blue line is the ground wire, the orange line is the neutral wire; D1 to D4 are the 1N4001 diodes, C1 to C3 are the capacitors; R refers to the resistor; Q refers to the transistors; L refers to the coils; D5 to D7 are the red light-emitting diodes).
Figure 3
Figure 3
Device shell scheme. Device case: aluminum. Projector material: hard plastic. Projector diameter: Φ = 32.90 mm. Projector length: 34.50 mm. Device size: 200.00 × 38.20 × 50.06 mm.
Figure 4
Figure 4
Printed circuit scheme, BKA-06 device, and schematic layout of the device.
Figure 5
Figure 5
Relationship between amperage and illuminance.
Figure 6
Figure 6
(a) BKA-06 equipment image that scans through layers of adult breast tissue. (b) Vascular screening on the surface of an adult’s arm using BKA-06 equipment. (c) Vascular screening on an adult’s hand using BKA-06 equipment. (d) Vascular screening on a child’s hands using BKA-06 equipment. (e) The thermal images of blood vessels illuminated by BKA-06 on (A1, C, and D) a child’s forearm and (A2, E, and F) adult’s breast.
Figure 7
Figure 7
Breast test photos of volunteer no. 9.
Figure 8
Figure 8
Summary of breast cancer test results using the BKA-06 device.
Figure 9
Figure 9
Images of (a) MRI scans, (b) BKA-06, and (c) cell biopsies of breast cancer patient no. 6.
Figure 10
Figure 10
Images of MRI scans, BKA-06, and cell biopsies of breast cancer patient no. 7.
Figure 11
Figure 11
BKA-06 image of patient no. 7.
Figure 12
Figure 12
Images of MRI scans, BKA-06, and cell biopsies of breast cancer patients.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Duong Thi Tuan A. Assessment of the Actual Situation of Performing Intravenous Injection Procedures by Nurses in Construction Hospitals. KHKT Publisher; Hanoi, Vietnam: 2011.
    1. Dang Thi Thanh T. Knowledge, Skills to Practice Safe Injection and Some Related Factors of Students at Kon Tum Medical Secondary School in 2016. KHKT Publisher; Hanoi, Vietnam: 2016. pp. 12–14.
    1. Heer E., Harper A., Escandor N., Sung H., McCormack V., Fidler-Benaoudia M.M. Global burden and trends in premenopausal and postmenopausal breast cancer: A population-based study. Lancet Glob. Health. 2020;8:e1027–e1037. doi: 10.1016/S2214-109X(20)30215-1. - DOI - PubMed
    1. Anderson B.O., Ilbawi A.M., Fidarova E., Weiderpass E., Stevens L., Abdel-Wahab M., Mikkelsen B. The Global Breast Cancer Initiative: A strategic collaboration to strengthen health care for non-communicable diseases. Lancet. Oncol. 2021;22:578–581. doi: 10.1016/S1470-2045(21)00071-1. - DOI - PubMed
    1. Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA A Cancer J. Clin. 2018;68:394–424. doi: 10.3322/caac.21492. - DOI - PubMed

LinkOut - more resources