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Review
. 2023 Nov 20;12(22):7194.
doi: 10.3390/jcm12227194.

Treatment Approaches to Molar Incisor Hypomineralization: A Systematic Review

Angelo Michele Inchingolo  1 , Alessio Danilo Inchingolo  1 , Fabio Viapiano  1 , Anna Maria Ciocia  1 , Irene Ferrara  1 , Anna Netti  1 , Gianna Dipalma  1 , Andrea Palermo  2 , Francesco Inchingolo  1
Affiliations
Review

Treatment Approaches to Molar Incisor Hypomineralization: A Systematic Review

Angelo Michele Inchingolo et al. J Clin Med. .

Abstract

Aim: This systematic review aimed to comprehensively evaluate the available literature on treating molar incisor hypomineralization (MIH) or enamel hypomineralization published between 2013 and 2023, focusing on identifying relevant studies and their characteristics.

Materials and methods: The search process encompassed reputable academic databases, including PubMed, Scopus, Cochrane Library, and Web of Science, using a precise keyword strategy ("((molar incisor hypomineralization) OR (enamel hypomineralization)) AND (treatment)"). A total of 637 articles were initially retrieved, followed by a strict selection process adhering to PRISMA guidelines. The inclusion criteria encompassed Randomized Control Trials (RCTs), case series with more than five clinical cases (CSs), studies involving human participants, availability as free full-text or accessible with university credentials, and English-language publications. Exclusion criteria included systematic or literature reviews, editorials, single-case reports, studies conducted in vitro, those involving animals, paid articles, and non-English-language publications.

Results: The search yielded 864 articles, of which 23 met the stringent inclusion criteria after a meticulous selection process. These studies will serve as the basis for a comprehensive analysis of MIH treatment approaches. The systematic review ensures the quality and relevance of the chosen studies for a detailed assessment of MIH treatment strategies.

Conclusions: This systematic review will provide valuable insights into the characteristics of selected studies, patient profiles, and available treatment options for molar incisor hypomineralization, contributing to a better understanding of this dental condition's management.

Keywords: caseine; children; enamel defect; enamel hypomineralization; fluoride; molar incisor hypomineralization; pediatric dentistry; preventive therapies; restorative therapies; sealant; therapy; treatment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Examples of clinical manifestation of MIH: (A) mild, (B) moderate, (C) severe.
Figure 2
Figure 2
Examples of clinical manifestation of incisor affected by MIH.
Figure 3
Figure 3
PRISMA flowchart diagram of the inclusion process.
Figure 4
Figure 4
Risk of bias [3,57,64,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90].
See this image and copyright information in PMC

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