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Review
. 2023 Nov 11;24(22):16197.
doi: 10.3390/ijms242216197.

Advances in Intercellular Communication Mediated by Exosomal ncRNAs in Cardiovascular Disease

Xiaoyan Zhang  1   2 , Shengjie Sun  2 , Gang Ren  2 , Wujun Liu  1 , Hong Chen  1
Affiliations
Review

Advances in Intercellular Communication Mediated by Exosomal ncRNAs in Cardiovascular Disease

Xiaoyan Zhang et al. Int J Mol Sci. .

Abstract

Cardiovascular diseases are a leading cause of worldwide mortality, and exosomes have recently gained attention as key mediators of intercellular communication in these diseases. Exosomes are double-layered lipid vesicles that can carry biomolecules such as miRNAs, lncRNAs, and circRNAs, and the content of exosomes is dependent on the cell they originated from. They can be involved in the pathophysiological processes of cardiovascular diseases and hold potential as diagnostic and monitoring tools. Exosomes mediate intercellular communication, stimulate or inhibit the activity of target cells, and affect myocardial hypertrophy, injury and infarction, ventricular remodeling, angiogenesis, and atherosclerosis. Exosomes can be released from various types of cells, including endothelial cells, smooth muscle cells, cardiomyocytes, fibroblasts, platelets, adipocytes, immune cells, and stem cells. In this review, we highlight the communication between different cell-derived exosomes and cardiovascular cells, with a focus on the roles of RNAs. This provides new insights for further exploring targeted therapies in the clinical management of cardiovascular diseases.

Keywords: cardiovascular disease; circRNAs; exosomes; intercellular communication; lncRNAs; miRNAs.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structure, composition, secretion, and cellular entry of exosomes. Note: (A) means early endosomes, (B) means multivesicular bodies (MVBs), (C) means late endosomes and (D) means recipient cells.
Figure 2
Figure 2
Schematic diagram of intercellular communication mediated by exosomal ncRNAs in cardiovascular disease.
See this image and copyright information in PMC

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