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Review
. 2023 Nov 9;13(11):1586.
doi: 10.3390/jpm13111586.

miRNA-Based Technologies in Cancer Therapy

Maria Pagoni  1 , Claudia Cava  2 , Diamantis C Sideris  3 , Margaritis Avgeris  4 , Vassilios Zoumpourlis  5 , Ioannis Michalopoulos  6 , Nikolaos Drakoulis  1
Affiliations
Review

miRNA-Based Technologies in Cancer Therapy

Maria Pagoni et al. J Pers Med. .

Abstract

The discovery of therapeutic miRNAs is one of the most exciting challenges for pharmaceutical companies. Since the first miRNA was discovered in 1993, our knowledge of miRNA biology has grown considerably. Many studies have demonstrated that miRNA expression is dysregulated in many diseases, making them appealing tools for novel therapeutic approaches. This review aims to discuss miRNA biogenesis and function, as well as highlight strategies for delivering miRNA agents, presenting viral, non-viral, and exosomic delivery as therapeutic approaches for different cancer types. We also consider the therapeutic role of microRNA-mediated drug repurposing in cancer therapy.

Keywords: cancer; miRNA.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of miRNA therapeutic strategies: 1. anti-miRNA oligonucleotides (AMOs) bind with miRNA, preventing the binding of miRNA to mRNA; 2. miRNA sponges include multiple sites for miRNA binding, blocking the binding of miRNA to mRNA; 3. miRNA mask binds with the specific gene (target of miRNA).
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