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. 2023 Nov 6;13(11):2172.
doi: 10.3390/life13112172.

Obesity and Bone Mineral Density Protection Paradox in Chronic Kidney Disease: Secreted Protein Acidic and Rich in Cysteine as a Piece of the Puzzle?

Abdelaziz Ghanemi  1   2 , Fabrice Mac-Way  1   2
Affiliations

Obesity and Bone Mineral Density Protection Paradox in Chronic Kidney Disease: Secreted Protein Acidic and Rich in Cysteine as a Piece of the Puzzle?

Abdelaziz Ghanemi et al. Life (Basel). .

Abstract

Obesity is a health condition that represents a risk factor for numerous diseases and complications. However, obesity might also have-to some extent-some "benefits" in certain situations. This includes potential bone protection in patients suffering from chronic kidney disease. In an attempt to explain such a paradox, we highlight secreted protein acidic and rich in cysteine (SPARC) as a hypothetical mediator of this protection. Indeed, SPARC properties provide a logical rationale to describe such bone protection via its overexpression combined with its calcium-binding and collagen-binding properties. We believe that exploring such hypotheses could open new doors to elucidate unknown pathways towards developing a new generation of molecular therapies.

Keywords: bone density protection; chronic kidney disease; obesity paradox; secreted protein acidic and rich in cysteine (SPARC/osteonectin).

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Hypothetical mechanisms of how the obesity-induced increased secreted protein acidic and rich in cysteine (SPARC) expression protects bones from chronic kidney disease-related density loss as well as SPARC contribution to vascular calcification.
See this image and copyright information in PMC

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