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Review
. 2023 Oct 27;15(11):2540.
doi: 10.3390/pharmaceutics15112540.

Pharmacogenetic Guidelines for Psychotropic Drugs: Optimizing Prescriptions in Clinical Practice

Antoine Baldacci  1 , Emeric Saguin  1 , Alexander Balcerac  2 , Stéphane Mouchabac  3   4 , Florian Ferreri  3   4 , Raphael Gaillard  5 , Marie-Dominique Colas  6 , Hervé Delacour  6   7 , Alexis Bourla  3   4   8   9
Affiliations
Review

Pharmacogenetic Guidelines for Psychotropic Drugs: Optimizing Prescriptions in Clinical Practice

Antoine Baldacci et al. Pharmaceutics. .

Abstract

The modalities for prescribing a psychotropic (dose and choice of molecule) are currently unsatisfactory, which can lead to a lack of efficacy of the treatment associated with prolonged exposure of the patient to the symptoms of his or her illness and the side effects of the molecule. In order to improve the quality of treatment prescription, a part of the current biomedical research is dedicated to the development of pharmacogenetic tools for individualized prescription. In this guideline, we will present the genes of interest with level 1 clinical recommendations according to PharmGKB for the two major families of psychotropics: antipsychotics and antidepressants. For antipsychotics, there are CYP2D6 and CYP3A4, and for antidepressants, CYP2B6, CYP2D6, and CYP2C19. The study will focus on describing the role of each gene, presenting the variants that cause functional changes, and discussing the implications for prescriptions in clinical practice.

Keywords: antidepressant; antipsychotics; cytochrome; pharmacogenetics; prescription assistance; psychotropic.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PhamGKB Clinical Annotation Level of Evidence.
See this image and copyright information in PMC

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References

    1. Rush A.J., Williams N.R., Heifets B.D., Blasey C., Sudheimer K., Pannu J., Pankow H., Hawkins J., Birnbaum J., Lyons D.M., et al. Acute and Longer-Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report. AJP. 2006;163:1905–1917. doi: 10.1176/ajp.2006.163.11.1905. - DOI - PubMed
    1. Lieberman J.A., Stroup T.S., McEvoy J.P., Swartz M.S., Rosenheck R.A., Perkins D.O., Keefe R.S.E., Davis S.M., Davis C.E., Lebowitz B.D., et al. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N. Engl. J. Med. 2005;353:1209–1223. doi: 10.1056/NEJMoa051688. - DOI - PubMed
    1. Kennedy S.H., Lam R.W., McIntyre R.S., Tourjman S.V., Bhat V., Blier P., Hasnain M., Jollant F., Levitt A.J., MacQueen G.M., et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 3. Pharmacological Treatments. Can. J. Psychiatry. 2016;61:540–560. doi: 10.1177/0706743716659417. - DOI - PMC - PubMed
    1. Mishra S., Swain T.R., Mohanty M. Adverse drug reaction monitoring of antidepressants in the psychiatry outpatients department of a tertiary care teaching hospital. J. Clin. Diagn. Res. 2013;7:1131–1134. doi: 10.7860/JCDR/2013/4985.3041. - DOI - PMC - PubMed
    1. Adverse Effects of Antipsychotic Medications—PubMed. [(accessed on 15 May 2023)]; Available online: https://pubmed.ncbi.nlm.nih.gov/20187598/

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