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. 2023 Nov 9;28(22):7498.
doi: 10.3390/molecules28227498.

Dissipation and Dietary Risk Assessment of Prochloraz in Strawberries under Greenhouse Conditions

Hui Wang  1 , Jian Sun  2 , Qingju Liu  1 , Cheng Li  1 , Yunxia Luan  1
Affiliations

Dissipation and Dietary Risk Assessment of Prochloraz in Strawberries under Greenhouse Conditions

Hui Wang et al. Molecules. .

Abstract

Prochloraz and its metabolites in strawberries have not been determined until now. Meanwhile, few reports in the literature have concerned the dissipation behavior and risk assessment of prochloraz and its metabolites in strawberries under greenhouse conditions in Beijing. A method for the determination of prochloraz and its metabolites in strawberries was developed using QuEChERS in combination with ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Prochloraz and its metabolites recovered from strawberries were present in concentrations of 73.06% to 116.01%, their RSDs ranged from 1.12% to 9.17%, and their limits of detection ranged from 0.1 to 1 μg kg-1. Then, a study was conducted on the dissipation of prochloraz in strawberries under greenhouse conditions. The dissipation of prochloraz in strawberries followed the first-order kinetic equation, and its half-life was 8.06 days. The health risk associated with prochloraz in strawberries was evaluated using the target hazard quotient (THQ) method and EFSA PRIMo model. The results showed that the THQ values, %ARfD values, and %ADI values were less than 1. These results indicate that no health concerns of prochloraz are associated with the consumption of the studied strawberries. The government can use the results of this study to support the establishment of a maximum residue level for prochloraz in strawberries.

Keywords: dissipation; metabolites; prochloraz; risk assessment; strawberry.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structural formulas of prochloraz and its metabolites.
Figure 2
Figure 2
Dynamic curve of dissipation of prochloraz in strawberries.
Figure 3
Figure 3
Dissipation of prochloraz and its metabolites in strawberries.
See this image and copyright information in PMC

References

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