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Review
. 2023 Oct 24;11(11):1631.
doi: 10.3390/vaccines11111631.

The Application of Mesenchymal Stem Cells in Future Vaccine Synthesis

Rui Zhang  1 , Xingxiang Duan  1 , Ye Liu  1 , Jia Xu  2 , Abdullkhaleg Ali Ghaleb Al-Bashari  1 , Peng Ye  3 , Qingsong Ye  1 , Yan He  4
Affiliations
Review

The Application of Mesenchymal Stem Cells in Future Vaccine Synthesis

Rui Zhang et al. Vaccines (Basel). .

Abstract

Vaccines have significant potential in treating and/or preventing diseases, yet there remain challenges in developing effective vaccines against some diseases, such as AIDS and certain tumors. Mesenchymal stem cells (MSCs), a subset of cells with low immunogenicity, high proliferation potential, and an abundant source of extracellular vesicles (EVs), represent one of the novel and promising vaccine platforms. This review describes the unique features and potential mechanisms of MSCs as a novel vaccine platform. We also cover aspects such as the safety and stability of MSCs that warrant future in-depth studies.

Keywords: EVs; anti-cancer; antigen delivery; mesenchymal stem cells; vaccine.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1
Figure 1
EVs contain abundant nucleic acid chains and proteins, making them very suitable for use as vaccine vectors.
Figure 2
Figure 2
Engineered MSC vaccines targeted drug and antigen delivery. Expression of pathogen antigens (including spike protein and receptor on the membrane surface or antigens).
Figure 3
Figure 3
MSC vaccine synthesis anti-tumor mechanism.
See this image and copyright information in PMC

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References

    1. Masalova O.V., Lesnova E.I., Klimova R.R., Momotyuk E.D., Kozlov V.V., Ivanova A.M., Payushina O.V., Butorina N.N., Zakirova N.F., Narovlyansky A.N., et al. Genetically Modified Mouse Mesenchymal Stem Cells Expressing Non-Structural Proteins of Hepatitis C Virus Induce Effective Immune Response. Vaccines. 2020;8:62. doi: 10.3390/vaccines8010062. - DOI - PMC - PubMed
    1. MacDonald N.E., Eskola J., Liang X., Chaudhuri M., Dube E., Gellin B., Goldstein S., Larson H., Manzo M.L., Reingold A., et al. Vaccine hesitancy: Definition, scope and determinants. Vaccine. 2015;33:4161–4164. doi: 10.1016/j.vaccine.2015.04.036. - DOI - PubMed
    1. Vetter V., Denizer G., Friedland L.R., Krishnan J., Shapiro M. Understanding modern-day vaccines: What you need to know. Ann. Med. 2018;50:110–120. doi: 10.1080/07853890.2017.1407035. - DOI - PubMed
    1. Nayereh K.G., Khadem G. Preventive and Therapeutic Vaccines against Human Papillomaviruses Associated Cervical Cancers. Iran J. Basic Med. Sci. 2012;15:585–601. - PMC - PubMed
    1. Su P., Wu Y., Xie F., Zheng Q., Chen L., Liu Z., Meng X., Zhou F., Zhang L. A Review of Extracellular Vesicles in COVID-19 Diagnosis, Treatment, and Prevention. Adv. Sci. 2023;10:e2206095. doi: 10.1002/advs.202206095. - DOI - PMC - PubMed

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