Role of Immunoglobulin A in COVID-19 and Influenza Infections

doi:10.3390/vaccines11111647

Editorial

. 2023 Oct 27;11(11):1647.

doi: 10.3390/vaccines11111647.

Role of Immunoglobulin A in COVID-19 and Influenza Infections

Rohit Tyagi¹, Srijani Basu², Atika Dhar³, Suman Gupta⁴, Sneh Lata Gupta⁵, Rishi K Jaiswal⁶

Affiliations

¹ College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
² Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
³ National Institutes of Health, Bethesda, MD 20892, USA.
⁴ Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
⁵ National Institute of Immunology, New Delhi 110067, India.
⁶ Department of Cancer Biology, Cardinal Bernardin Cancer Center, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA.

PMID: 38005979
PMCID: PMC10675305
DOI: 10.3390/vaccines11111647

Editorial

Role of Immunoglobulin A in COVID-19 and Influenza Infections

Rohit Tyagi et al. Vaccines (Basel). 2023.

. 2023 Oct 27;11(11):1647.

doi: 10.3390/vaccines11111647.

Authors

Rohit Tyagi¹, Srijani Basu², Atika Dhar³, Suman Gupta⁴, Sneh Lata Gupta⁵, Rishi K Jaiswal⁶

Affiliations

¹ College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
² Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
³ National Institutes of Health, Bethesda, MD 20892, USA.
⁴ Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
⁵ National Institute of Immunology, New Delhi 110067, India.
⁶ Department of Cancer Biology, Cardinal Bernardin Cancer Center, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA.

PMID: 38005979
PMCID: PMC10675305
DOI: 10.3390/vaccines11111647

Abstract

Immunoglobulin A (IgA) is critical in the immune response against respiratory infections like COVID-19 and influenza [...].

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Various vaccine strategies being developed against Influenza and SARS-CoV-2. Both virues have distinct surface protein structure which have been used to detect and classify various viral strains. The current vaccinestrategies include utilizing different approaches to elicit prolonged neutralizing antibodytiters.

See this image and copyright information in PMC

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References

1. Gupta S.L., Jaiswal R.K. Relevant of neutralizing antibody during SARS-CoV-2 infection and their therapeutic usage. Mol. Biol. Rep. 2022;49:10137–10140. doi: 10.1007/s11033-022-07493-z. - DOI - PMC - PubMed
1. Zorgi N.E., Meireles L.R., Oliveira D.B.L., Araujo D.B., Durigon E.L., de Andrade Junior H.F. Isolated specific IgA against respiratory viruses, Influenza or SARS-CoV-2, present in the saliva of a fraction of healthy and asymptomatic volunteers. Clinics. 2022;77:100105. doi: 10.1016/j.clinsp.2022.100105. - DOI - PMC - PubMed
1. Sterlin D., Mathian A., Miyara M., Mohr A., Anna F., Claër L., Quentric P., Fadlallah J., Devilliers H., Ghillani P., et al. IgA dominates the early neutralizing antibody response to SARS-CoV-2. Sci. Transl. Med. 2021;13:eabd2223. doi: 10.1126/scitranslmed.abd2223. - DOI - PMC - PubMed
1. Quinti I., Mortari E.P., Fernandez Salinas A., Milito C., Carsetti R. IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection. Front. Cell. Infect. Microbiol. 2021;11:655896. doi: 10.3389/fcimb.2021.655896. - DOI - PMC - PubMed
1. Montague B.T., Wipperman M.F., Chio E., Crow R., Hooper A.T., O’Brien M.P., Simões E.A.F. Elevated serum IgA following vaccination against SARS-CoV-2 in a cohort of high-risk first responders. Sci. Rep. 2022;12:14932. doi: 10.1038/s41598-022-19095-7. - DOI - PMC - PubMed

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[1] Gupta S.L., Jaiswal R.K. Relevant of neutralizing antibody during SARS-CoV-2 infection and their therapeutic usage. Mol. Biol. Rep. 2022;49:10137–10140. doi: 10.1007/s11033-022-07493-z. - DOI - PMC - PubMed

[2] Gupta S.L., Jaiswal R.K. Relevant of neutralizing antibody during SARS-CoV-2 infection and their therapeutic usage. Mol. Biol. Rep. 2022;49:10137–10140. doi: 10.1007/s11033-022-07493-z. - DOI - PMC - PubMed

[3] Zorgi N.E., Meireles L.R., Oliveira D.B.L., Araujo D.B., Durigon E.L., de Andrade Junior H.F. Isolated specific IgA against respiratory viruses, Influenza or SARS-CoV-2, present in the saliva of a fraction of healthy and asymptomatic volunteers. Clinics. 2022;77:100105. doi: 10.1016/j.clinsp.2022.100105. - DOI - PMC - PubMed

[4] Zorgi N.E., Meireles L.R., Oliveira D.B.L., Araujo D.B., Durigon E.L., de Andrade Junior H.F. Isolated specific IgA against respiratory viruses, Influenza or SARS-CoV-2, present in the saliva of a fraction of healthy and asymptomatic volunteers. Clinics. 2022;77:100105. doi: 10.1016/j.clinsp.2022.100105. - DOI - PMC - PubMed

[5] Sterlin D., Mathian A., Miyara M., Mohr A., Anna F., Claër L., Quentric P., Fadlallah J., Devilliers H., Ghillani P., et al. IgA dominates the early neutralizing antibody response to SARS-CoV-2. Sci. Transl. Med. 2021;13:eabd2223. doi: 10.1126/scitranslmed.abd2223. - DOI - PMC - PubMed

[6] Sterlin D., Mathian A., Miyara M., Mohr A., Anna F., Claër L., Quentric P., Fadlallah J., Devilliers H., Ghillani P., et al. IgA dominates the early neutralizing antibody response to SARS-CoV-2. Sci. Transl. Med. 2021;13:eabd2223. doi: 10.1126/scitranslmed.abd2223. - DOI - PMC - PubMed

[7] Quinti I., Mortari E.P., Fernandez Salinas A., Milito C., Carsetti R. IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection. Front. Cell. Infect. Microbiol. 2021;11:655896. doi: 10.3389/fcimb.2021.655896. - DOI - PMC - PubMed

[8] Quinti I., Mortari E.P., Fernandez Salinas A., Milito C., Carsetti R. IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection. Front. Cell. Infect. Microbiol. 2021;11:655896. doi: 10.3389/fcimb.2021.655896. - DOI - PMC - PubMed

[9] Montague B.T., Wipperman M.F., Chio E., Crow R., Hooper A.T., O’Brien M.P., Simões E.A.F. Elevated serum IgA following vaccination against SARS-CoV-2 in a cohort of high-risk first responders. Sci. Rep. 2022;12:14932. doi: 10.1038/s41598-022-19095-7. - DOI - PMC - PubMed

[10] Montague B.T., Wipperman M.F., Chio E., Crow R., Hooper A.T., O’Brien M.P., Simões E.A.F. Elevated serum IgA following vaccination against SARS-CoV-2 in a cohort of high-risk first responders. Sci. Rep. 2022;12:14932. doi: 10.1038/s41598-022-19095-7. - DOI - PMC - PubMed

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Role of Immunoglobulin A in COVID-19 and Influenza Infections

Affiliations

Role of Immunoglobulin A in COVID-19 and Influenza Infections

Authors

Affiliations

Abstract

Conflict of interest statement

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