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. 2024:2729:3-13.
doi: 10.1007/978-1-0716-3499-8_1.

11C-Fixation Techniques

Emily Murrell  1 , Anton Lindberg  1 , Armando Garcia  1 , Neil Vasdev  2   3
Affiliations

11C-Fixation Techniques

Emily Murrell et al. Methods Mol Biol. 2024.

Abstract

This protocol describes the application of cyclotron-generated [11C]CO2 fixation reactions for direct 11C-carboxylation reactions and [11C]CO for 11C-carbonylations. Herein we describe one-pot methods wherein the radioactive gas is first trapped in a reaction mixture at room temperature and atmospheric pressure prior to the radiolabeling reactions. Such procedures are widely applicable to numerous small molecules to form 11C-labeled carboxylic acids, amides, esters, ketones, oxazolidinones, carbamates, and ureas. The steps for 11C-fixation techniques described herein are tailored for a commercial automated synthesis unit and are readily adapted for routine radiopharmaceutical production.

Keywords: Carbon dioxide; Carbon monoxide; Carbon-11; Carbonylation; Carboxylation.

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