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Review
. 2024 Jan:193:104213.
doi: 10.1016/j.critrevonc.2023.104213. Epub 2023 Nov 24.

The relation between excess adiposity and breast cancer in women: Clinical implications and management

Maria D Hurtado  1 , Elif Tama  2 , Stacey D'Andre  3 , Chrisandra L Shufelt  4
Affiliations
Review

The relation between excess adiposity and breast cancer in women: Clinical implications and management

Maria D Hurtado et al. Crit Rev Oncol Hematol. 2024 Jan.

Abstract

Background: Breast cancer (BC) is the most common cancer in women. While the combination of improved screening, earlier detection, and advances in therapeutics has resulted in lower BC mortality, BC survivors are now increasingly dying of cardiovascular disease. Cardiovascular disease in the leading cause of non-cancer related mortality among BC survivors. This situation underscores the critical need to research the role of modifiable cardiometabolic risk factors, such as excess adiposity, that will affect BC remission, long-term survivorship, and overall health and quality of life.

Purpose: First, this review summarizes the evidence on the connection between adipose tissue and BC. Then we review the data on weight trends after BC diagnosis with a focus on the effect of weight gain on BC recurrence and BC- and non-BC-related death. Finally, we provide a guide for weight management in BC survivors, considering the available data on the effect of weight loss interventions on BC.

Keywords: Adiposity; Breast; Breast cancer; Mortality; Recurrence; Weight loss.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1.
Figure 1.. The relation Between Increased Lifetime Estrogen Exposure and Breast Cancer Risk
Figure 2.
Figure 2.. Types of Bariatric Surgery
See this image and copyright information in PMC

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