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Observational Study
. 2023 Nov 26;28(1):541.
doi: 10.1186/s40001-023-01528-2.

Higher plasma aldosterone concentrations in patients with aortic diseases and hypertension: a retrospective observational study

Yuting Pu  1   2 , Guifang Yang  1   2 , Xiaogao Pan  1   2 , Yang Zhou  1   2 , Aifang Zhong  1   2 , Ning Ding  1   2 , Yingjie Su  1   2 , Wen Peng  1   2 , Mengping Zeng  1   2 , Tuo Guo  1   2 , Xiangping Chai  3   4
Affiliations
Observational Study

Higher plasma aldosterone concentrations in patients with aortic diseases and hypertension: a retrospective observational study

Yuting Pu et al. Eur J Med Res. .

Abstract

Background: Aortic diseases remain a highly perilous macrovascular condition. The relationship between circulating aldosterone and aortic diseases is rarely explored, thus we investigated the difference in plasma aldosterone concentration (PAC) between patients with and without aortic disease in hypertensive people.

Methods: We analyzed 926 patients with hypertension, ranging in age from 18 to 89 years, who had their PAC measured from the hospital's electronic database. The case group and control group were defined based on inclusion and exclusion criteria. The analysis included general information, clinical data, biochemical data, and medical imaging examination results as covariates. To further evaluate the difference in PAC between primary hypertension patients with aortic disease and those without, we used multivariate logistic regression analysis and also employed propensity score matching to minimize the influence of confounding factors.

Results: In total, 394 participants were included in the analysis, with 66 individuals diagnosed with aortic diseases and 328 in the control group. The participants were predominantly male (64.5%) and over the age of 50 (68.5%), with an average PAC of 19.95 ng/dL. After controlling for confounding factors, the results showed hypertension patients with aortic disease were more likely to have high PAC levels than those without aortic disease (OR = 1.138, 95% CI [1.062 to 1.238]). Subgroup analysis revealed consistent relationship between PAC and primary hypertensive patients with aortic disease across the different stratification variables. Additionally, hypertensive patients with aortic disease still have a risk of higher PAC levels than those without aortic disease, even after propensity score matching.

Conclusions: The results of this study suggest that primary hypertensive patients with aortic diseases have elevated levels of PAC, but the causal relationship between PAC and aortic disease requires further study.

Keywords: Aldosterone; Aortic diseases; Aortic dissection; Hypertension.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Fig. 1
Fig. 1
Flowchart of patient enrollment
Fig. 2
Fig. 2
Subgroup analysis. BMI body mass index
See this image and copyright information in PMC

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