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Randomized Controlled Trial
. 2023 Nov;29(11):e13531.
doi: 10.1111/srt.13531.

Oral administration of hyaluronic acid to improve skin conditions via a randomized double-blind clinical test

Yan-Rui Gao  1 , Rui-Ping Wang  2 , Lu Zhang  3 , Yuan Fan  3 , Jin Luan  3 , Zhe Liu  3 , Chao Yuan  1
Affiliations
Randomized Controlled Trial

Oral administration of hyaluronic acid to improve skin conditions via a randomized double-blind clinical test

Yan-Rui Gao et al. Skin Res Technol. 2023 Nov.

Abstract

Objective: To evaluate the impact of oral intake of Hyaluronic Acid (HA) on skin health.

Background: HA, an endogenous substance in the human body, plays a key role in skin health. However, its concentration in the skin decreases significantly with age. Previous studies suggested that oral intake of HA can supplement the body's HA level, but did not reveal the effects on different age groups and skin types.

Methods: A double-blind, randomized clinical trial with 129 female participants, covering young and elderly groups and differnet skin types, was conducted to assess the efficacy of orally administered HA on skin health.

Results: Oral administration of HA significantly promoted skin hydration after 2-8 weeks among both young and elderly groups. Skin tone improvement was observed after 4-8 weeks, while an increase in epidermal thickness was noted after 12 weeks.

Conclusion: This study provides direct evidence supporting the clinical efficacy of oral intake of HA in promoting skin health.

Keywords: clinical benefit; hyaluronan; hyaluronic acid; oral administration; skin health.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

FIGURE 1
FIGURE 1
Skin hydration results of the young group by corneometer. (A) dry skin, placebo; (B) dry skin, 100 mg/day; (C) dry skin, 200 mg/day; (D) oily skin, placebo; (E) oily skin, 100 mg/day; (F) oily skin, 200 mg/day; (G) normal skin, placebo; (H) normal skin, 100 mg/day; (I) normal skin, 200 mg/day. Compared to 0 week * p < 0.05, ** p < 0.01.
FIGURE 2
FIGURE 2
Skin hydration results of the elderly group by corneometer. (A) dry skin, placebo; (B) dry skin, 100 mg/day; (C) dry skin, 200 mg/day; (D) oily skin, placebo; (E) oily skin, 100 mg/day; (F) oily skin, 200 mg/day; (G) normal skin, placebo; (H) normal skin, 100 mg/day; (I) normal skin, 200 mg/day. Compared to 0 week * p < 0.05, ** p < 0.01.
FIGURE 3
FIGURE 3
Skin hydration results with combined skin types. (A) young group, 100 mg/day; (B) elderly group, 100 mg/day; (C) young group, 200 mg/day; (D) elderly group, 200 mg/day. Compared to 0 week * p < 0.05.
FIGURE 4
FIGURE 4
Visia and ultrasound skin diagnostic photos of subjects in the low dose and high dose groups.
See this image and copyright information in PMC

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