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Multicenter Study
. 2024 Mar;164(3):1019-1027.
doi: 10.1002/ijgo.15250. Epub 2023 Nov 27.

The effect of body mass index on maternal and perinatal outcomes in COVID-19 infection during pregnancy and postpartum: Secondary analysis from the REBRACO cohort study

Thais G Sardinha  1 , Giuliane J Lajos  1 , Renato T Souza  1 , Jose G Cecatti  1 , Adriana G Luz  1 , Maria Lúcia R Oppermann  2 , Rodolfo C Pacagnella  1 , Carolina C Ribeiro-Do-Valle  1 , Guilherme M Nobrega  1 , Thayna B Griggio  1 , Charles M Charles  1 , Carla Silveira  1 , Maria J Miele  1 , Ricardo P Tedesco  3 , Karayna G Fernandes  3 , Sérgio Ha Martins-Costa  2 , Frederico Ja Peret  4 , Francisco E Feitosa  5 , Evelyn Traina  6 , Edson V Cunha Filho  7 , Janete Vettorazzi  2   7 , Samira M Haddad  8 , Carla B Candreucci  9 , José P Guida  1   10 , Mario D Correa Junior  11 , Marcos Ab Dias  12 , Leandro G Oliveira  13 , Elias F Melo Junior  14 , Marília Gq Da Luz  15 , Maria Laura Costa  1 ; REBRACO Study Group
Collaborators, Affiliations
Multicenter Study

The effect of body mass index on maternal and perinatal outcomes in COVID-19 infection during pregnancy and postpartum: Secondary analysis from the REBRACO cohort study

Thais G Sardinha et al. Int J Gynaecol Obstet. 2024 Mar.

Abstract

Objectives: To compare maternal and perinatal outcomes among women with obesity, overweight, and normal body mass index, associated with COVID-19 infection during pregnancy and postpartum.

Method: Prospective Cohort Study, within the REBRACO (Brazilian Network of COVID-19 in Pregnancy) multicenter initiative. Confirmed positive cases of SARS-CoV-2 were included, and women categorized into three groups according to their pre-pregnancy BMI: obesity (BMI ≥ 30), overweight (BMI <30 but >25), and normal BMI. Sociodemographic, clinical, and obstetric characteristics and different maternal and perinatal outcomes were compared, and a multiple regression analysis was performed to investigate factors independently associated with adverse maternal and perinatal outcomes.

Results: Two hundred eighty-nine women positive for SARS-CoV-2 infection were considered, and 202 had available data on maternal BMI for the current analysis. Overall, 72 (35.6%)obese, 68 (33.6%) overweight, and 60 (29.7%) normal BMI. Obesity was associated with increased adverse clinical outcomes including sepsis (P = 0.02), acute respiratory distress syndrome (P = 0.002), and the need for mechanical ventilation (P = 0.044). Considering perinatal outcomes, a multiple regression model confirmed obesity as an independent factor associated with adverse results (adjusted odds ratio 3.73, 95% CI 1.54-9.08).

Conclusion: Obesity and overweight were associated with worse clinical outcomes, severe/critical COVID-19, and adverse perinatal outcomes.

Keywords: COVID-19; obesity; overweight; postpartum; pregnancy.

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References

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