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. 1986 Oct 1;239(1):229-32.
doi: 10.1042/bj2390229.

Sex- and phenotype-dependent metabolism of N tau-methylhistidine by mice

C I Harris, G J Rucklidge, R M McDiarmid, G Milne

Sex- and phenotype-dependent metabolism of N tau-methylhistidine by mice

C I Harris et al. Biochem J. .

Abstract

The metabolism of N tau-[Me-14C]methylhistidine by mice was influenced by both the sex and the phenotype of the animal. After subcutaneous injection of labelled N tau-methylhistidine, recoveries of radioactivity in excreta were incomplete, and the distributions of radioactivity showed that different mouse phenotypes degraded N tau-methylhistidine in vivo to different extents. Hence the excretion of N tau-methylhistidine by mice cannot be used as an index of protein breakdown in vivo.

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