Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 May;36(5):e24023.
doi: 10.1002/ajhb.24023. Epub 2023 Nov 27.

Differential sex-association between PCSK1 polymorphisms and obesity risk in Portuguese children

Licínio Manco  1   2 , David Albuquerque  1 , Beatriz Aranda  1 , Daniela Rodrigues  1 , Aristides M Machado-Rodrigues  1   3 , Cristina Padez  1   2
Affiliations

Differential sex-association between PCSK1 polymorphisms and obesity risk in Portuguese children

Licínio Manco et al. Am J Hum Biol. 2024 May.

Abstract

Objectives: The proprotein convertase subtilisin/Kexin type 1 gene (PCSK1) is implicated in hypothalamic appetite control. Several studies have addressed the relationship between PCSK1 polymorphisms and obesity, although conflicting results were observed. We tested the potential association of four PCSK1 variants with the risk of overweight/obesity and related variables in Portuguese children.

Methods: This is a case-control study, where four PCSK1 variants, rs6230 (c.-101T>C), rs6232 (p.N221D), rs6235 (p.S690T), and rs3811942 (c.*265T>C), were analyzed in Portuguese children (aged 5-13 years-old). Anthropometric measures were objectively collected and used to provide weight-for-age, height-for-age, and body mass index (BMI) for age. The indices generated were compared to standard reference values of WHO to obtain the corresponding Z-scores.

Results: Logistic regression, in the dominant model, revealed no significant associations between the four individual PCSK1 variants and the risk of overweight/obesity in the total population. However, stratifying the sample by sex, a marginally significant association was found between the rs6235 minor C-allele and increased overweight/obesity in boys (n = 345) (OR 1.55 [1.01-2.38] p = .044), but not in girls (n = 340) (OR 0.73 [0.46-1.14] p = .169). Consistently, boys with genotype GG presented lower BMI Z-score (0.62) when compared to those with the genotypes GC + CC (1.04). Testing for different effects in males versus females, a significant interaction was found between the rs6235 polymorphism and sex for BMI Z-score (p = .025).

Conclusions: Results of this study suggest for a sex-differentiated association between PCSK1 rs6235 and overweight/ obesity in Portuguese children.

PubMed Disclaimer

References

REFERENCES

    1. Albuquerque, D., Nóbrega, C., & Manco, L. (2013). Association of FTO polymorphisms with obesity and obesity‐related outcomes in Portuguese children. PLoS One, 8(1), e54370. https://doi.org/10.1371/journal.pone.0054370
    1. Benzinou, M., Creemers, J. W., Choquet, H., Lobbens, S., Dina, C., Durand, E., Guerardel, A., Boutin, P., Jouret, B., Heude, B., Balkau, B., Tichet, J., Marre, M., Potoczna, N., Horber, F., Le Stunff, C., Czernichow, S., Sandbaek, A., Lauritzen, T., … Froguel, P. (2008). Common nonsynonymous variants in PCSK1 confer risk of obesity. Nature Genetics, 40(8), 943–945. https://doi.org/10.1038/ng.177
    1. Castro, G. V., Latorre, A. F. S., Korndorfer, F. P., de Carlos Back, L. K., & Lofgren, S. E. (2021). The impact of variants in four genes: MC4R, FTO, PPARG and PPARGC1A in overweight and obesity in a large sample of the Brazilian population. Biochemical Genetics, 59(6), 1666–1679. https://doi.org/10.1007/s10528-021-10079-2
    1. Chang, K., Khandpur, N., Neri, D., Touvier, M., Huybrechts, I., Millett, C., & Vamos, E. P. (2021). Association between childhood consumption of ultraprocessed food and adiposity trajectories in the avon longitudinal study of parents and children birth cohort. JAMA Pediatrics, 175(9), e211573. https://doi.org/10.1001/jamapediatrics.2021.1573
    1. Chang, Y. C., Chiu, Y. F., Shih, K. C., Lin, M. W., Sheu, W. H., Donlon, T., Curb, J. D., Jou, Y. S., Chang, T. J., Li, H. Y., & Chuang, L. M. (2010). Common PCSK1 haplotypes are associated with obesity in the Chinese population. Obesity (Silver Spring, MD), 18(7), 1404–1409. https://doi.org/10.1038/oby.2009.390

Publication types

MeSH terms

Substances

LinkOut - more resources