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. 2023 Nov;61(6):e23572.
doi: 10.1002/dvg.23572. Epub 2023 Nov 27.

Ascidian gene regulation and bioadhesion

Ute Rothbächer  1   2
Affiliations

Ascidian gene regulation and bioadhesion

Ute Rothbächer. Genesis. 2023 Nov.
No abstract available

Keywords: adhesive glue; bioadhesion; cis-regulatory mechanisms; collocytes; evolutionary conservation; gene regulation; sensory adhesive organ.

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Figures

FIGURE 1
FIGURE 1
The Innsbruck Tunicate lab today: from left to right, Alessandro Pennati (PhD candidate), David Feldmann and Luca Ciampa (Master students), Ute Rothbächer (group leader), Fan Zeng (postdoc) and Laura Kaczmarek (rotation student).
FIGURE 2
FIGURE 2
(a,b) Three sensory adhesive papillae of a Ciona larva show collocytes and the anterior hyaline cap (to the left) containing adhesive material marked by peanut agglutinin (PNA, red), while (b) axial columnar cells (ACCs) are marked by an anti‐ßγ‐crystallin (green) antibody (Zeng, Wunderer, Salvenmoser, Hess, et al., 2019). Scale bars 5 μm. (c) A control CRISPR electroporated Ciona tadpole shows normal expression of the Hmx cis‐regulatory region driving expression of the reporter gene lacZ in bipolar tail neurons (BTNs), (d) CRISPR knockout of Neurogenin abolishes expression of Hmx that is required for bipolar tail neuron specification, a sensory cell population that shares Hmx gene expression with vertebrate cranial sensory ganglia of placodal origin. The conservation of cis‐regulatory elements suggests a shared evolutionary ancestry of these cell types (Papadogiannis et al., 2022).
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