The impact of three carbapenems at a single-day dose on intestinal colonization resistance against carbapenem-resistant Klebsiella pneumoniae
- PMID: 38009993
- PMCID: PMC10732052
- DOI: 10.1128/msphere.00479-23
The impact of three carbapenems at a single-day dose on intestinal colonization resistance against carbapenem-resistant Klebsiella pneumoniae
Abstract
The intestinal colonization of carbapenem-resistant Klebsiella pneumoniae (CRKP) is an important source of clinical infection. Our research showed that even single-day dose use of carbapenems caused CRKP colonization and continuous bacterial shedding, which reminds clinical doctors to prescribe carbapenems cautiously. Whenever possible, ertapenem should be the preferred choice over other carbapenems especially when the identified or highly suspected pathogens can be effectively targeted by ertapenem.
Keywords: 16S rRNA; CRKP; carbapenem; colonization resistance; intestinal microbiota.
Conflict of interest statement
The authors declare no conflict of interest.
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