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. 2024 Mar;79(3):552-564.
doi: 10.1111/all.15961. Epub 2023 Nov 27.

Hypersensitivity reactions to proton pump inhibitors. An EAACI position paper

Sevim Bavbek  1 , Seçil Kepil Özdemir  2 , Patrizia Bonadonna  3 , Marina Atanaskovic-Markovic  4 , Annick Barbaud  5 , Knut Brockow  6 , Jose Laguna Martinez  7 , Alla Nakonechna  8 , Mauro Pagani  9 , Alessandra Arcolacı  10 , Carla Lombardo  11 , Maria J Torres  12
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Hypersensitivity reactions to proton pump inhibitors. An EAACI position paper

Sevim Bavbek et al. Allergy. 2024 Mar.

Abstract

Proton pump inhibitors (PPIs) are invaluable therapeutic options in a variety of dyspeptic diseases. In addition to their well-known risk profile, PPI consumption is related to food and environmental allergies, dysbiosis, osteoporosis, as well as immediate and delayed hypersensitivity reactions (HSRs). The latter, although a rare event, around 1%-3%, due to the extraordinarily high rate of prescription and consumption of PPIs are related to a substantial risk. In this Position Paper, we provide clinicians with practical evidence-based recommendations for the diagnosis and management of HSRs to PPIs. Furthermore, the unmet needs proposed in the document aim to stimulate more in-depth investigations in the topic.

Keywords: allergy; anaphylaxis; drug hypersensitivity; hypersensitivity reaction; proton pump inhibitors.

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References

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