SARS-CoV-2 antibody determination in a vaccinated and recovered cohort in Austria

Abstract

Since December 2019 the world has been dealing with a severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) pandemic. The first SARS-CoV-2 vaccine was made available in Europe at the end of 2020. 202 volunteers from the vicinity of the University of Applied Sciences Wiener Neustadt took part in this study; their IgG levels recognizing the RBD of SARS-CoV-2 were determined. The aim was to evaluate the SARS-CoV-2 titer levels of vaccinated, recovered and vaccinated plus recovered persons. We could show that there is a significant difference in the antibody levels of vaccinated, vaccinated plus recovered and only recovered probands. Additionally, the highest antibody levels were found in triple vaccinated persons. Furthermore, the Moderna vaccine seems to have a higher immune response.

Keywords: IgG determination; RBD; SARS-CoV-2; Vaccine.

Fig. 1

Months between the last vaccination and the breakthrough infection

Fig. 2

Boxblot of the titer of recovered, vaccinated and recovered/vaccinated probands

Fig. 3

Antibody titer in relation to the timepoint of the last contact with the pathogen or the last vaccination, respectively.

Fig. 4

Antibody titer and time point of the last vaccination

Fig. 5

Antibody titer according to the received doses

Fig. 6

Antibody titer according to the vaccine combinations