Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Mar;31(3):274-279.
doi: 10.1111/iju.15346. Epub 2023 Nov 28.

Differences in overall survival of penile cancer patients versus population-based controls

Lukas Scheipner  1   2 , Stefano Tappero  1   3   4 , Mattia Luca Piccinelli  1   5   6 , Francesco Barletta  1   7   8 , Cristina Cano Garcia  1   9 , Reha-Baris Incesu  1   10 , Simone Morra  1   11 , Zhe Tian  1 , Fred Saad  1 , Shahrokh F Shariat  12   13   14   15 , Carlo Terrone  3   4 , Ottavio De Cobelli  5   16 , Alberto Briganti  7 , Felix K H Chun  8 , Derya Tilki  9   17   18 , Nicola Longo  10 , Maximilian Seles  2 , Sascha Ahyai  2 , Pierre I Karakiewicz  1
Affiliations

Differences in overall survival of penile cancer patients versus population-based controls

Lukas Scheipner et al. Int J Urol. 2024 Mar.

Abstract

Purpose: To assess whether 5-year overall survival (OS) of squamous cell carcinoma of the penis (SCCP) patients differs from age-matched male population-based controls.

Methods: We relied on the Surveillance Epidemiology and End Results database (2004-2018) to identify newly diagnosed (2004-2013) SCCP patients. For each case, we simulated an age-matched control (Monte Carlo simulation), relying on the Social Security Administration (SSA) Life Tables with 5 years of follow-up. We compared OS between SCCP patients and population-based controls in a stage-specific fashion. Smoothed cumulative incidence plots displayed cancer-specific mortality (CSM) versus other-cause mortality (OCM).

Results: Of 2282 SCCP patients, the stage distribution was as follows: stage I 976 (43%) versus stage II 826 (36%) versus stage III 302 (13%) versus stage IV 178 (8%). At 5 years, OS of SCCP patients versus age-matched population-based controls was as follows: stage I 63% versus 80% (Δ = 17%), stage II 50% versus 80% (Δ = 30%), stage III 39% versus 84% (Δ = 45%), stage IV 26% versus 87% (Δ = 61%). At 5 years, CSM versus OCM in SCCP patients according to stage was as follows: stage I 12% versus 24%, stage II 22% versus 28%, stage III 47% versus 14%, and stage IV 60% versus 14%.

Conclusion: SCCP patients exhibit worse OS across all stages. The difference in OS at 5 years between SCCP and age-matched male population-based controls ranged from 17% to 61%. At 5 years, CSM accounted for 12% to 60% of all deaths, across all stages.

Keywords: CSM; OCM; SEER; penile cancer; population; survival.

PubMed Disclaimer

References

REFERENCES

    1. Social Security Administration. Actuarial life table [Internet]. [cited 2022 Jul 12]. Available from: https://www.ssa.gov/oact/STATS/table4c6.html
    1. Howlader N, Noone AM, Krapcho M, Miller D, Brest A, Yu M, et al. Cancer statistics review, 1975-2018-SEER statistics. [cited 2022 Dec 7]. Available from https://seer.cancer.gov/archive/csr/1975_2018/
    1. Preisser F, Bandini M, Mazzone E, Nazzani S, Marchioni M, Tian Z, et al. Validation of the Social Security Administration life tables (2004-2014) in localized prostate cancer patients within the surveillance, epidemiology, and end results database. Eur Urol Focus. 2019;5:807-814. [cited 2022 Nov 30]. Available from: https://pubmed.ncbi.nlm.nih.gov/29802052/
    1. Chierigo F, Borghesi M, Würnschimmel C, Flammia RS, Horlemann B, Sorce G, et al. Life expectancy in metastatic urothelial bladder cancer patients according to race/ethnicity. Int Urol Nephrol. 2022;54:1521-1527. [cited 2022 Nov 30]. Available from: https://pubmed.ncbi.nlm.nih.gov/35508792/
    1. Würnschimmel C, Wenzel M, Collà Ruvolo C, Nocera L, Tian Z, Saad F, et al. Life expectancy in metastatic prostate cancer patients according to racial/ethnic groups. Int J Urol [Internet]. 2021;28:862-869. [cited 2022 Nov 30]; Available from: https://pubmed.ncbi.nlm.nih.gov/33993551/

LinkOut - more resources