Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Dec 5;12(23):e032146.
doi: 10.1161/JAHA.123.032146. Epub 2023 Nov 28.

Patient-Reported Outcomes in Venous Thromboembolism: A Systematic Review of the Literature, Current Challenges, and Ways Forward

Daniel J Snyder  1 , Robert S Zilinyi  2 , David J Cohen  3   4 , Sahil A Parikh  2 , Sanjum S Sethi  2
Affiliations

Patient-Reported Outcomes in Venous Thromboembolism: A Systematic Review of the Literature, Current Challenges, and Ways Forward

Daniel J Snyder et al. J Am Heart Assoc. .

Abstract

Background: Venous thromboembolism (VTE) affects >1.2 million Americans annually. Although the clinical outcomes and economic burdens of VTE have been well described, the impact of VTE on patients' health status has yet to be summarized. This systematic review summarizes how patient-reported outcome measures (PROMs) have been used in VTE to date.

Methods and results: PubMed/MEDLINE was queried for literature published through March 2023 using PROMs in a population of patients with VTE. Studies were excluded if the reference was an editorial, review, or case report, or if the study included patients with conditions other than VTE. Qualitative analyses were performed. After screening and exclusion, 136 references were identified; 5 described PROM development, 20 focused on PROM validation, and 111 used PROMs in outcomes research. The most used generic PROMs were the 36-item Short-Form Health Survey and EuroQol 5-dimensional questionnaire, and the most common disease-specific PROMs were the Venous Insufficiency Epidemiological and Economic Study-Quality of Life/Symptoms and the Pulmonary Embolism Quality of Life Questionnaire. PROMs were used to quantify the changes in health status after diagnosis, characterize the trajectory of subsequent improvement, and identify drivers of continued impairments in health status like postthrombotic syndrome and postpulmonary embolism syndrome. PROMs were also used to investigate the impact of novel treatment modalities on quality of life.

Conclusions: This review demonstrates the many benefits of PROM use, including quantifying changes in health status with treatment, capturing patients' experiences with the treatment itself, and identifying complications of VTE. Incorporating PROMs into VTE care will be an essential component of evaluating the effectiveness of novel therapies and should lead to improved shared decision-making for patients with VTE.

Keywords: patient‐reported outcome measures; patient‐reported outcomes; pulmonary embolism; venous thromboembolism.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Preferred Reporting Items for Systematic Review and Meta‐Analysis diagram.
See this image and copyright information in PMC

References

    1. Virani SS, Alonso A, Aparicio HJ, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Cheng S, et al. Heart disease and stroke statistics—2021 update: a report from the American Heart Association. Circulation. 2021;143:E254–E743. doi: 10.1161/CIR.0000000000000950 - DOI - PubMed
    1. Secemsky EA, Rosenfield K, Kennedy KF, Jaff M, Yeh RW. High burden of 30‐day readmissions after acute venous thromboembolism in the United States. J Am Heart Assoc. 2018;7:e009047. doi: 10.1161/JAHA.118.009047 - DOI - PMC - PubMed
    1. Grosse SD, Nelson RE, Nyarko KA, Richardson LC, Raskob GE. The economic burden of incident venous thromboembolism in the United States: a review of estimated attributable healthcare costs. Thromb Res. 2016;137:3–10. doi: 10.1016/j.thromres.2015.11.033 - DOI - PMC - PubMed
    1. Mohr DN, Silverstein MD, Heit JA, Petterson TM, Michael O'Fallon W, Joseph ML. The venous stasis syndrome after deep venous thrombosis or pulmonary embolism: a population‐based study. Mayo Clin Proc. 2000;75:1249–1256. doi: 10.4065/75.12.1249 - DOI - PubMed
    1. Rabinovich A, Kahn SR. The postthrombotic syndrome: current evidence and future challenges. J Thromb Haemost. 2017;15:230–241. doi: 10.1111/jth.13569 - DOI - PubMed

Publication types

MeSH terms

LinkOut - more resources