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. 2023 Nov 28;25(1):42 - 49.
doi: 10.5152/ThoracResPract.2023.23104.

A Narrative Review of the Clinical Trials in Sleep-Related Breathing Disorders from 2022 to Present

Aylin Pıhtılı  1 , Canan Gündüz Gürkan  2 , Mehmet Ali Habeşoğlu  3 , Önder Öztürk  4 , Aylin Özsancak Uğurlu  3 , Mehmet Sezai Taşbakan  5 , Yüksel Peker  6 , On Behalf Of The Turkish Thoracic Society Sleep Related Breathing Disorders Working Group  7
Affiliations

A Narrative Review of the Clinical Trials in Sleep-Related Breathing Disorders from 2022 to Present

Aylin Pıhtılı et al. Thorac Res Pract. .

Abstract

Sleep-related breathing disorders (SRBD) comprise obstructive sleep apnea (OSA), central sleep apnea (CSA), obesity-hypoventilation syndrome (OHS), as well as isolated sleep-related hypoxemia (ISRH), according to the recent International Classification of Sleep Disorders 3. During the last decades, there have been cumulative research reports indicating an association between the SRBD and increased cardiometabolic illness and death, as well as decreased quality of life. Notwithstanding, the results have been inconclusive, and the evidence level was not high regarding the effect of treatment for the SRBD on adverse outcomes. In the current work, we aim to give a comprehensive review of the clinical trials published from January 2022 to August 31, 2023. We highlight the heterogeneity of cardiometabolic disorders among adults with SRBD and particularly emphasize OSA management, drug therapy for OSA, positive airway pressure (PAP) therapy and cardiovascular outcomes, other effects of PAP in pregnancy and neurocognitive function, as well as the effects of surgical treatment and oral appliances. We also underline future directions in OSA management, telemonitoring, and druginduced sleep endoscopy in managing the SRBD, especially OSA. We ascertain that more studies are needed within the CSA, OHS, and ISRH research fields.

Keywords: Sleep-related breathing disorders; obstructive sleep apnea; cardiovascular; drug therapy; telemedicine.

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Conflict of interest statement

Declaration of Interests: Y.P. declares institutional grants from the ResMed Foundation outside the submitted work. Other authors declare no conflict of interest.

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