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Review
. 2023 Dec 1;211(12):890-895.
doi: 10.1097/NMD.0000000000001624.

Pathophysiological Hypothesis of COVID-19 Psychosis

Gisela Roxana Edith Lisi  1 , Francisco Appiani  1 , María Eugenia Basile  2 , Marcelo Garro  1 , Juan Manuel Duarte  1
Affiliations
Review

Pathophysiological Hypothesis of COVID-19 Psychosis

Gisela Roxana Edith Lisi et al. J Nerv Ment Dis. .

Abstract

In December 2019, a new coronavirus called SARS-CoV-2 was discovered in patients with pneumonia of unknown cause. Although respiratory symptoms mainly characterize infection by this virus, neuropsychiatric manifestations of the disease are becoming more and more frequent. Among them, the appearance of psychotic outbreaks in patients experiencing the infection or after a short time after it has resolved is remarkable. This narrative review aims to describe the possible relationship between SARS-CoV-2 and the onset of psychosis by developing the neurotropic capacities of the virus and analyzing the neurobiology of psychoses.

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