Precision net ultrafiltration dosing in continuous kidney replacement therapy: a practical approach

doi:10.1186/s40635-023-00566-8

. 2023 Nov 28;11(1):83.

doi: 10.1186/s40635-023-00566-8.

Precision net ultrafiltration dosing in continuous kidney replacement therapy: a practical approach

Raghavan Murugan^{1

2}, Kianoush Kashani³, Paul M Palevsky^{4

5

6}

Affiliations

¹ The Program for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America. muruganr@upmc.edu.
² The Center for Research, Investigation, and Systems Modeling of Acute Illness (CRISMA), Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America. muruganr@upmc.edu.
³ Division of Nephrology and Hypertension, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.
⁴ The Program for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
⁵ Renal and Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
⁶ Kidney Medicine Section, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, United States of America.

PMID: 38015332
PMCID: PMC10684837
DOI: 10.1186/s40635-023-00566-8

Precision net ultrafiltration dosing in continuous kidney replacement therapy: a practical approach

Raghavan Murugan et al. Intensive Care Med Exp. 2023.

. 2023 Nov 28;11(1):83.

doi: 10.1186/s40635-023-00566-8.

Authors

Raghavan Murugan^{1

2}, Kianoush Kashani³, Paul M Palevsky^{4

5

6}

Affiliations

¹ The Program for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America. muruganr@upmc.edu.
² The Center for Research, Investigation, and Systems Modeling of Acute Illness (CRISMA), Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America. muruganr@upmc.edu.
³ Division of Nephrology and Hypertension, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.
⁴ The Program for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
⁵ Renal and Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
⁶ Kidney Medicine Section, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, United States of America.

PMID: 38015332
PMCID: PMC10684837
DOI: 10.1186/s40635-023-00566-8

No abstract available

Keywords: Acute kidney injury; Continuous kidney replacement therapy; Net fluid removal; Net ultrafiltration; Ultrafiltration rate.

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Conflict of interest statement

RM, KK, and PMP filed an international patent application for the method of fluid removal described herein (Patent no. PCT/US2023/012204). RM received research grants from NIDDK and consulting fees from Baxter Inc., AM Pharma Inc., Bioporto Inc. and La Jolla Inc., unrelated to this study. KK received research grants NIDDK and from, Philips Research North America, and Google, a speaker honorarium from Nikkiso Critical Care Medical Supplies (Shanghai) Co., Ltd, and consulting fees to Mayo Clinic and from Baxter Inc.; PMP received consulting fees and advisory committee fees from Durect, Health-Span Dx, and Novartis; served on a Data and Safety Monitoring Board for Baxter; served as a member of an endpoint adjudication committee for GE Healthcare.

Cited by

Behind the scenes: Key lessons learned from the RELIEVE-AKI clinical trial.
Nikravangolsefid N, Suppadungsuk S, Singh W, Palevsky PM, Murugan R, Kashani KB. Nikravangolsefid N, et al. J Crit Care. 2024 Oct;83:154845. doi: 10.1016/j.jcrc.2024.154845. Epub 2024 Jun 15. J Crit Care. 2024. PMID: 38879964 Review.
Correspondence regarding the article by Murugan et al. on "Precision net ultrafiltration dosing in continuous kidney replacement therapy: a practical approach".
Bellomo R; Rational Evaluation of Nomenclature and Agreement based on Logic (RENAL) Investigators. Bellomo R, et al. Intensive Care Med Exp. 2024 Feb 20;12(1):18. doi: 10.1186/s40635-023-00585-5. Intensive Care Med Exp. 2024. PMID: 38376740 Free PMC article. No abstract available.
Protocolized fluid balance neutralization during continuous renal replacement therapy.
Murugan R, Prowle J, Beaubien-Souligny W. Murugan R, et al. Intensive Care Med. 2024 Dec;50(12):2141-2143. doi: 10.1007/s00134-024-07698-9. Epub 2024 Oct 31. Intensive Care Med. 2024. PMID: 39480517 No abstract available.
Response Letter to: Correspondence regarding the article by Murugan et al on Precision net ultrafiltration dosing in continuous kidney replacement therapy: a practical approach.
Murugan R, Kashani K, Palevsky PM. Murugan R, et al. Intensive Care Med Exp. 2024 Feb 20;12(1):17. doi: 10.1186/s40635-023-00588-2. Intensive Care Med Exp. 2024. PMID: 38376597 Free PMC article. No abstract available.

References

1. Murugan R, Balakumar V, Kerti SJ, Priyanka P, Chang CH, Clermont G, Bellomo R, Palevsky PM, Kellum JA. Net ultrafiltration intensity and mortality in critically ill patients with fluid overload. Crit Care. 2018;22:223. doi: 10.1186/s13054-018-2163-1. - DOI - PMC - PubMed
1. Balakumar V, Murugan R, Sileanu FE, Palevsky P, Clermont G, Kellum JA. Both positive and negative fluid balance may be associated with reduced long-term survival in the critically ill. Crit Care Med. 2017;45:e749–e757. doi: 10.1097/CCM.0000000000002372. - DOI - PMC - PubMed
1. (2012) Kidney Disease Improving Global Outcomes (KDIGO) Workgroup: Clinical Practice Guideline for Acute Kidney Injury. Kidney Int Suppl. 2: 1–138
1. Murugan R, Hoste E, Mehta RL, Samoni S, Ding X, Rosner MH, Kellum JA, Ronco C, Acute Disease Quality Initiative Consensus G Precision Fluid Management in Continuous Renal Replacement Therapy. Blood Purif. 2016;42:266–278. doi: 10.1159/000448528. - DOI - PubMed
1. Rosner MH, Ostermann M, Murugan R, Prowle JR, Ronco C, Kellum JA, Mythen MG, Shaw AD, Group AXI Indications and management of mechanical fluid removal in critical illness. Br J Anaesth. 2014;113:764–771. doi: 10.1093/bja/aeu297. - DOI - PubMed

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[1] Murugan R, Balakumar V, Kerti SJ, Priyanka P, Chang CH, Clermont G, Bellomo R, Palevsky PM, Kellum JA. Net ultrafiltration intensity and mortality in critically ill patients with fluid overload. Crit Care. 2018;22:223. doi: 10.1186/s13054-018-2163-1. - DOI - PMC - PubMed

[2] Murugan R, Balakumar V, Kerti SJ, Priyanka P, Chang CH, Clermont G, Bellomo R, Palevsky PM, Kellum JA. Net ultrafiltration intensity and mortality in critically ill patients with fluid overload. Crit Care. 2018;22:223. doi: 10.1186/s13054-018-2163-1. - DOI - PMC - PubMed

[3] Balakumar V, Murugan R, Sileanu FE, Palevsky P, Clermont G, Kellum JA. Both positive and negative fluid balance may be associated with reduced long-term survival in the critically ill. Crit Care Med. 2017;45:e749–e757. doi: 10.1097/CCM.0000000000002372. - DOI - PMC - PubMed

[4] Balakumar V, Murugan R, Sileanu FE, Palevsky P, Clermont G, Kellum JA. Both positive and negative fluid balance may be associated with reduced long-term survival in the critically ill. Crit Care Med. 2017;45:e749–e757. doi: 10.1097/CCM.0000000000002372. - DOI - PMC - PubMed

[5] (2012) Kidney Disease Improving Global Outcomes (KDIGO) Workgroup: Clinical Practice Guideline for Acute Kidney Injury. Kidney Int Suppl. 2: 1–138

[6] (2012) Kidney Disease Improving Global Outcomes (KDIGO) Workgroup: Clinical Practice Guideline for Acute Kidney Injury. Kidney Int Suppl. 2: 1–138

[7] Murugan R, Hoste E, Mehta RL, Samoni S, Ding X, Rosner MH, Kellum JA, Ronco C, Acute Disease Quality Initiative Consensus G Precision Fluid Management in Continuous Renal Replacement Therapy. Blood Purif. 2016;42:266–278. doi: 10.1159/000448528. - DOI - PubMed

[8] Murugan R, Hoste E, Mehta RL, Samoni S, Ding X, Rosner MH, Kellum JA, Ronco C, Acute Disease Quality Initiative Consensus G Precision Fluid Management in Continuous Renal Replacement Therapy. Blood Purif. 2016;42:266–278. doi: 10.1159/000448528. - DOI - PubMed

[9] Rosner MH, Ostermann M, Murugan R, Prowle JR, Ronco C, Kellum JA, Mythen MG, Shaw AD, Group AXI Indications and management of mechanical fluid removal in critical illness. Br J Anaesth. 2014;113:764–771. doi: 10.1093/bja/aeu297. - DOI - PubMed

[10] Rosner MH, Ostermann M, Murugan R, Prowle JR, Ronco C, Kellum JA, Mythen MG, Shaw AD, Group AXI Indications and management of mechanical fluid removal in critical illness. Br J Anaesth. 2014;113:764–771. doi: 10.1093/bja/aeu297. - DOI - PubMed

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Precision net ultrafiltration dosing in continuous kidney replacement therapy: a practical approach

Affiliations

Precision net ultrafiltration dosing in continuous kidney replacement therapy: a practical approach

Authors

Affiliations

Conflict of interest statement

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