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. 2023 Nov 28;3(11):e0001358.
doi: 10.1371/journal.pgph.0001358. eCollection 2023.

Rotavirus genotypes in children under five years hospitalized with diarrhea in low and middle-income countries: Results from the WHO-coordinated Global Rotavirus Surveillance Network

Sebastien Antoni  1 , Tomoka Nakamura  1   2   3 , Adam L Cohen  1 , Jason M Mwenda  4 , Goitom Weldegebriel  5 , Joseph N M Biey  6 , Keith Shaba  4 , Gloria Rey-Benito  7 , Lucia Helena de Oliveira  7 , Maria Tereza da Costa Oliveira  7 , Claudia Ortiz  7 , Amany Ghoniem  8 , Kamal Fahmy  8 , Hossam A Ashmony  8 , Dovile Videbaek  9 , Danni Daniels  9 , Roberta Pastore  9 , Simarjit Singh  9 , Emmanuel Tondo  10 , Jayantha B L Liyanage  10 , Mohammed Sharifuzzaman  10 , Varja Grabovac  11 , Nyambat Batmunkh  11 , Josephine Logronio  11 , George Armah  12 , Francis E Dennis  12 , Mapaseka Seheri  13 , Nonkululeko Magagula  13 , Jeffrey Mphahlele  13 , Jose Paulo G Leite  14 , Irene T Araujo  14 , Tulio M Fumian  14 , Hanan El Mohammady  15 , Galina Semeiko  16 , Elena Samoilovich  16 , Sidhartha Giri  17 , Gagandeep Kang  17 , Sarah Thomas  18 , Julie Bines  18 , Carl D Kirkwood  18 , Na Liu  19 , Deog-Yong Lee  20 , Mirren Iturriza-Gomara  21 , Nicola Anne Page  22   23 , Mathew D Esona  24 , M Leanne Ward  24 , Courtnee N Wright  24 , Slavica Mijatovic-Rustempasic  24 , Jacqueline E Tate  24 , Umesh D Parashar  24 , Jon Gentsch  25 , Michael D Bowen  24 , Fatima Serhan  1
Affiliations

Rotavirus genotypes in children under five years hospitalized with diarrhea in low and middle-income countries: Results from the WHO-coordinated Global Rotavirus Surveillance Network

Sebastien Antoni et al. PLOS Glob Public Health. .

Abstract

Rotavirus is the most common pathogen causing pediatric diarrhea and an important cause of morbidity and mortality in low- and middle-income countries. Previous evidence suggests that the introduction of rotavirus vaccines in national immunization schedules resulted in dramatic declines in disease burden but may also be changing the rotavirus genetic landscape and driving the emergence of new genotypes. We report genotype data of more than 16,000 rotavirus isolates from 40 countries participating in the Global Rotavirus Surveillance Network. Data from a convenience sample of children under five years of age hospitalized with acute watery diarrhea who tested positive for rotavirus were included. Country results were weighted by their estimated rotavirus disease burden to estimate regional genotype distributions. Globally, the most frequent genotypes identified after weighting were G1P[8] (31%), G1P[6] (8%) and G3P[8] (8%). Genotypes varied across WHO Regions and between countries that had and had not introduced rotavirus vaccine. G1P[8] was less frequent among African (36 vs 20%) and European (33 vs 8%) countries that had introduced rotavirus vaccines as compared to countries that had not introduced. Our results describe differences in the distribution of the most common rotavirus genotypes in children with diarrhea in low- and middle-income countries. G1P[8] was less frequent in countries that had introduced the rotavirus vaccine while different strains are emerging or re-emerging in different regions.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Countries included in this analysis (2014–2018).
Fig 2
Fig 2. Distribution of the most common rotavirus A genotypes by World Health Organization Region, weighted (2014–2018).
AFR: African Region, AMR: Region of the Americas, EMR: Eastern Mediterranean Region, EUR: European Region, SEAR: South-East Asia Region, WPR: Western Pacific Region.
See this image and copyright information in PMC

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