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. 1987 Jan;103(1):35-8.

[Fibrinolytic action of an enzyme preparation covalently bound to modified thrombin]

[Article in Russian]
A V Maksimenko, A N Rusetskiĭ, V P Torchilin
  • PMID: 3801648

[Fibrinolytic action of an enzyme preparation covalently bound to modified thrombin]

[Article in Russian]
A V Maksimenko et al. Biull Eksp Biol Med. 1987 Jan.

Abstract

Successive thrombin modification by carbodiimide and aliphatic diamines decreases esterase and fibrin-coagulating activity of the enzyme. Modified thrombin causes no platelet aggregation. Water-soluble enzyme conjugates devoid of fibrinogen-coagulating action and possessing increased fibrinolytic affinity to the site of fibrin clot location have been obtained by covalent binding of chymotrypsin to modified thrombin.

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