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Review
. 2024;23(10):1234-1250.
doi: 10.2174/0118715273273539231114095300.

Natural Compounds as Inhibitors of Aβ Peptide and Tau Aggregation

Kadja Luana Chagas Monteiro  1 , Thiago Mendonça de Aquino  1 , Edeildo Ferreira da Silva-Júnior  2
Affiliations
Review

Natural Compounds as Inhibitors of Aβ Peptide and Tau Aggregation

Kadja Luana Chagas Monteiro et al. CNS Neurol Disord Drug Targets. 2024.

Abstract

Neurodegenerative conditions like Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) encompass disorders characterized by the degeneration of neurons in specific circumstances. The quest for novel agents to influence these diseases, particularly AD, has unearthed various natural compounds displaying multifaceted activities and diverse pharmacological mechanisms. Given the ongoing extensive study of pathways associated with the accumulation of neurofibrillary aggregates and amyloid plaques, this paper aims to comprehensively review around 130 studies exploring natural products. These studies focus on inhibiting the formation of amyloid plaques and tau protein tangles, with the objective of potentially alleviating or delaying AD.

Keywords: Alzheimer’s disease; cognitive decline; flavonoids; learning and memory.; neurodegeneration; polyphenols; tau protein.

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