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Review
. 2024;19(10):1293-1302.
doi: 10.2174/011574888X275737231120045815.

Identifying Dental Pulp Stem Cell as a Novel Therapeutic trategy for Digestive Diseases

Xieyin Sun  1 , Zhaoyi Lin  1 , Nuo Xu  1 , Yinqi Chen  1 , Saiyan Bian  1 , Wenjie Zheng  1   2
Affiliations
Review

Identifying Dental Pulp Stem Cell as a Novel Therapeutic trategy for Digestive Diseases

Xieyin Sun et al. Curr Stem Cell Res Ther. 2024.

Abstract

Mesenchymal stem cells (MSCs) have been identified as potential therapeutics for various diseases. In contrast to other sources of MSCs, dental stem cells (DSCs) have received increased attention due to their high activity and easy accessibility. Among them, dental pulp stem cells (DPSCs) exhibit superior self-renewal, multipotency, immunomodulatory, and regenerative capacities. Following their inspiring performance in animal models and clinical trials, DPSCs show pharmacological potential in regenerative medicine. In this review, we have generalized the sources, heterogeneity, and biological characteristics of DPSCs, as well as compared them with other types of dental stem cells. In addition, we summarized the application of DPSCs in digestive diseases (such as liver, esophageal, and intestinal diseases), highlighting their regenerative and pharmacological potential based on the existing preclinical and clinical evidence. Specifically, DPSCs can be home to injured or inflamed tissues and exert repair and regeneration functions by facilitating immune regulation, anti-inflammation, and directional differentiation. Although DPSCs have a rosy prospect, future studies should handle the underlying drawbacks and pave the way for the identification of DPSCs as novel regenerative medicine.

Keywords: Dental pulp stem cell; digestive diseases; mesenchymal stem cells (MSCs); pharmacological; regenerative medicine; regenerative medicine..

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References

    1. in ’t Anker P.S.; Scherjon S.A.; Kleijburg-van der Keur C.; Noort W.A.; Claas F.H.J.; Willemze R.; Fibbe W.E.; Kanhai H.H.H.; Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation. Blood 2003,102(4),1548-1549 - DOI - PubMed
    1. Secco M.; Zucconi E.; Vieira N.M.; Fogaça L.L.Q.; Cerqueira A.; Carvalho M.D.F.; Jazedje T.; Okamoto O.K.; Muotri A.R.; Zatz M.; Multipotent stem cells from umbilical cord: Cord is richer than blood!. Stem Cells 2008,26(1),146-150 - DOI - PubMed
    1. Gruber H.E.; Deepe R.; Hoelscher G.L.; Ingram J.A.; Norton H.J.; Scannell B.; Loeffler B.J.; Zinchenko N.; Hanley E.N.; Tapp H.; Human adipose-derived mesenchymal stem cells: Direction to a phenotype sharing similarities with the disc, gene expression profiling, and coculture with human annulus cells. Tissue Eng Part A 2010,16(9),2843-2860 - DOI - PubMed
    1. Friedenstein A.J.; Piatetzky-Shapiro I.I.; Petrakova K.V.; Osteogenesis in transplants of bone marrow cells. Development 1966,16(3),381-390 - DOI - PubMed
    1. Staniowski T.; Zawadzka-Knefel A.; Skośkiewicz-Malinowska K.; Therapeutic potential of dental pulp stem cells according to different transplant types. Molecules 2021,26(24),7423 - DOI - PubMed