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. 2023 Nov 29:13:04160.
doi: 10.7189/jogh.13.04160.

Global, regional, and national burden of neurological disorders in 204 countries and territories worldwide

Yi Huang #  1 , Yongan Li #  2 , Haiyan Pan  3   4 , Liyuan Han  5
Affiliations

Global, regional, and national burden of neurological disorders in 204 countries and territories worldwide

Yi Huang et al. J Glob Health. .

Abstract

Background: We aimed to determine the incidence and disability-adjusted life-years (DALYs) of neurological disorders worldwide from 1990 to 2019.

Methods: We obtained age-standardised incidence and DALY rates of neurological disorders in 204 countries and territories from 1990 to 2019 from the Global Burden of Disease (GBD) database. We determined trends stratified by age, sex, region, country, and Social Development Index (SDI) and the risk factors contributing to DALYs associated with these neurological disorders.

Results: The largest increases in the age-standardised incidence rates of neurological disorders in 1990-2019 occurred in four regions (East Asia: estimated annual percentage change (EAPC) = 0.19, tropical Latin America: EAPC = 0.07, Southern Latin America: EAPC = 0.03, Western Europe: EAPC = 0.03) and three countries (China: EAPC = 0.20, Ecuador: EAPC = 0.13, Italy: EAPC = 0.13). We observed the largest increases in age-standardised incidence rates for Parkinson disease, idiopathic epilepsy, and bipolar disorder, and in age-standardised DALY rates for Alzheimer disease and other dementias. High-SDI regions showed the highest EAPC for age-standardised incidence rates of Parkinson disease, depression, and motor neuron disease, and age-standardised DALY rates of neurological disorders.

Conclusions: There is a need to control the increase in age-standardised incidence rates of neurological disorders in East Asia, tropical Latin America, Southern Latin America, and Western Europe, particularly in China, Ecuador, and Italy.

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Conflict of interest statement

Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests.

Figures

Figure 1
Figure 1
EAPC of neurological disorders and its main subtypes, with age-standardised rates from 1990 to 2019: Panel A. EAPC of age-standardised incidence rate. Panel B. EAPC of age-standardisbahed DALY rate. EAPC – estimated annual percentage change, DALY – disability-adjusted life-year.
Figure 2
Figure 2
EAPC of neurological disorders and its main subtypes, with age-standardised incidence rate from 1990 to 2019 by region.
Figure 3
Figure 3
EAPC of neurological disorders and its main subtypes, with age-standardised DALY rate from 1990 to 2019 by region. DALY – disability adjusted life-year.
Figure 4
Figure 4
The incidence and DALY rates of neurological disorders and its main subtypes among different age groups.
Figure 5
Figure 5
The ranking of risk factors for age-standardised DALY rate attributable to neurological disorders according to region.
See this image and copyright information in PMC

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