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The study by Miladet al. presents data addressing how inhalation of cannabis smoke affects influenza infections in mice, and uncovers responses that are different in male and female mice https://bit.ly/46qpTis.
Nasrin S, Watson CJW, Perez-Paramo YX, et al. . Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis–drug interactions. Drug Metab Dispos 2021; 49: 1070–1080. doi:10.1124/dmd.121.000442
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Grotenhermen F. Pharmacokinetics and pharmacodynamics of cannabinoids. Clin Pharmacokinet 2003; 42: 327–360. doi:10.2165/00003088-200342040-00003
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Milad N, Fantauzzi MF, McGrath JJC, et al. . Cannabis smoke suppresses antiviral immune responses to influenza A in mice. ERJ Open Res 2023; 9: 00219-2023. doi:10.1183/23120541.00219-2023
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Karmaus PW, Chen W, Crawford R, et al. . Δ9-tetrahydrocannabinol impairs the inflammatory response to influenza infection: role of antigen-presenting cells and the cannabinoid receptors 1 and 2. Toxicol Sci 2013; 131: 419–433. doi:10.1093/toxsci/kfs315
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Karmaus PW, Chen W, Kaplan BL, et al. . Δ9-tetrahydrocannabinol suppresses cytotoxic T lymphocyte function independent of CB1 and CB 2, disrupting early activation events. J Neuroimmune Pharmacol 2012; 7: 843–855. doi:10.1007/s11481-011-9293-4
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