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. 2023 Mar 17;13(3):e134732.
doi: 10.5812/aapm-134732. eCollection 2023 Jun.

A Comparative Study on the Effect of Intrathecal Bupivacaine vs. Ropivacaine on Maternal and Neonatal Outcomes After Cesarean Section: A Systematic Review and Meta-analysis

Molouk Jaafarpour  1 , Aminolah Vasigh  2 , Fatemeh Najafi  3 , Hojat Sayadi  4   5 , Elham Shafiei  6
Affiliations

A Comparative Study on the Effect of Intrathecal Bupivacaine vs. Ropivacaine on Maternal and Neonatal Outcomes After Cesarean Section: A Systematic Review and Meta-analysis

Molouk Jaafarpour et al. Anesth Pain Med. .

Abstract

Context: The type of anesthesia in cesarean section can affect the mother and baby. This study aimed to determine the comparative effect of intrathecal hyperbaric bupivacaine vs. hyperbaric ropivacaine on maternal and neonatal outcomes after cesarean section.

Evidence acquisition: PubMed, Web of Science, Embase, Google Scholar, IranDoc, MagIran, and Scopus databases were searched from 1 September 2022 to 1 November 2022. Eighteen clinical trials with 1542 patients were included in the analysis.

Results: There was no statistically significant difference in hypotension, bradycardia, and Apgar score between the 2 groups (P > 0.05). The risk of nausea (relative risk (RR), 1.526; 95% CI, 1.175 - 1.981; P = 0.001) and vomiting (RR, 1.542; 95% CI, 1.048 - 2.268; P = 0.02) caused by bupivacaine was 0.53% and 0.54% higher than that of ropivacaine. The incidence of shivering (RR, 2.24; 95% CI, 1.480 - 3.39; P = 0.00) was 2.24 times higher in the bupivacaine group than in the ropivacaine group. The average onset time of sensory block (standardized mean difference (SMD), -0.550; 95% CI, -1.054 to -0.045; P = 0.032) and motor block (SMD, -0.812; 95% CI, -1.254 to -0.371; P = 0.000) was significantly lower in the bupivacaine group than in the ropivacaine group.

Conclusions: Despite the fact that ropivacaine and bupivacaine are effective in cesarean section, ropivacaine is more favorable because of less hemodynamic changes, less duration of sensory and motor block, and fewer side effects, which are effective in patient recovery.

Keywords: Bupivacaine; Cesarean Section; Mothers; Ropivacaine; Spinal Anesthesia.

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Conflict of interest statement

The authors declare no conflict of interests.

Figures

Figure 1.
Figure 1.. The flowchart of the study
Figure 2.
Figure 2.. Forest plot of hypotension
Figure 3.
Figure 3.. Forest plot of Apgar score at 1 minute
Figure 4.
Figure 4.. Forest plot of vomiting
Figure 5.
Figure 5.. Forest plot of onset motor block
Figure 6.
Figure 6.. Funnel plot of hypotension
See this image and copyright information in PMC

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