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Case Reports
. 2023 Oct 19;15(10):e47350.
doi: 10.7759/cureus.47350. eCollection 2023 Oct.

Pyopneumothorax Secondary to Pulmonary Tuberculosis Superadded by Congenital Factor XIII Deficiency: A Case Report

Jyoti Bajpai  1 , Jay Tewari  2 , Shubhajeet Roy  2 , Ajay K Verma  3 , Shailendra P Verma  4 , Surya Kant  1
Affiliations
Case Reports

Pyopneumothorax Secondary to Pulmonary Tuberculosis Superadded by Congenital Factor XIII Deficiency: A Case Report

Jyoti Bajpai et al. Cureus. .

Abstract

Pyopneumothorax is a rare complication of pulmonary tuberculosis, contributing significantly to morbidity and mortality. Additionally, factor XIII deficiency, a rare bleeding disorder, may pose a diagnostic challenge due to normal results in routine coagulation tests. We present the case of an 18-year-old boy who presented with a history of left-sided pyopneumothorax secondary to drug-sensitive Mycobacterium tuberculosis, complicated by congenital factor XIII deficiency. After three months of intercostal drainage placement, the patient developed severe anemia and bleeding tendencies, necessitating a referral to clinical hematology. Genetic testing revealed factor XIII deficiency. This case highlights the complicated interplay between tuberculosis-related complications and a coexisting genetic disorder, highlighting the importance of comprehensive clinical assessment and multidisciplinary management.

Keywords: autosomal inheritance; congenital disease; factor xiii deficiency; pyopneumothorax; tuberculosis.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Axial computerized tomography of the thorax in the lung window showing consolidation on the right side (red arrow), and pyopneumothorax with underlying consolidation on the left side (green arrow)
See this image and copyright information in PMC

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