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Review
. 2023 Nov 9:14:1286344.
doi: 10.3389/fimmu.2023.1286344. eCollection 2023.

Crosstalk: keratinocytes and immune cells in psoriasis

Masahiro Kamata  1 , Yayoi Tada  1
Affiliations
Review

Crosstalk: keratinocytes and immune cells in psoriasis

Masahiro Kamata et al. Front Immunol. .

Abstract

In the past, psoriasis was considered a skin disease caused only by keratinocyte disorders. However, the efficacy of immunosuppressive drugs and biologics used to treat psoriasis proves that psoriasis is an immune-mediated disease. Indeed, a variety of immune cells are involved in the pathogenesis of psoriasis, including dendritic cells, Th17 cells, and resident memory T cells. Furthermore, keratinocytes play a role in the development of psoriasis as immune cells by secreting antibacterial peptides, chemokines, tumor necrosis factor-α, interleukin (IL)-36, and IL-23. These immune cells and skin cells interact and drive the aberrant differentiation and proliferation of keratinocytes. This crosstalk between keratinocytes and immune cells critical in the pathogenesis of psoriasis forms an inflammatory loop, resulting in the persistence or exacerbation of psoriasis plaques.

Keywords: crosstalk; immune cell; keratinocyte; psoriasis; skin cell.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Crosstalk from immune cells to keratinocytes in psoriasis. A variety of immune cells affect keratinocytes in psoriasis. IL, interleukin; TNF, tumor necrosis factor; NKT, natural killer T; MAIT, mucosal-associated invariant T.
Figure 2
Figure 2
Crosstalk from keratinocytes to immune cells in psoriasis. Activated keratinocytes produce antibacterial peptides, chemokines, and inflammatory cytokines, and affect immune cells in psoriasis. pDC, plasmacytoid dendritic cell; mDC, myeloid DC; CXCL, C-X-C motif chemokine ligand; CCL, C-C motif chemokine ligand; IL, interleukin; TNF, tumor necrosis factor.
See this image and copyright information in PMC

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