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Case Reports
. 2023 Nov 21;15(11):e49205.
doi: 10.7759/cureus.49205. eCollection 2023 Nov.

Childhood-Onset Systemic Lupus Erythematosus Presenting With Concomitant Gastrointestinal Manifestation and Antiphospholipid Syndrome

Nur Diyana Mohd Shukri  1 , Wan Majdiah Wan Mohamad  2 , Wan Suriana Wan Ab Rahman  2
Affiliations
Case Reports

Childhood-Onset Systemic Lupus Erythematosus Presenting With Concomitant Gastrointestinal Manifestation and Antiphospholipid Syndrome

Nur Diyana Mohd Shukri et al. Cureus. .

Abstract

Childhood-onset systemic lupus erythematosus is a rare disease that is more prevalent in Southeast Asian children than in Western children. It is characterised by a peripubertal onset and a female predominance that rises with age. Haematological, renal, and mucocutaneous are among the frequently involved organs upon diagnosis. Some of the typical symptoms include cutaneous vasculitis, malar rash, and fever. Patients frequently had proliferative class IV lupus nephritis, which increases disease activity and kidney damage. We reported a child presented with fever associated with multiple joint pain, skin rashes over the fingers of the right hand, and generalised abdominal pain.

Keywords: antiphospholipid syndrome; autoimmune disease; childhood-onset sle; gastrointestinal manifestation; systemic lupus erythematosus.

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Conflict of interest statement

The authors have declared that no competing interests exist.

References

    1. Childhood-onset systemic lupus erythematosus: Southeast Asian perspectives. Tang SP, Lim SC, Arkachaisri T. J Clin Med. 2021;10:559. - PMC - PubMed
    1. Taxonomy for systemic lupus erythematosus with onset before adulthood. Silva CA, Avcin T, Brunner HI. Arthritis Care Res (Hoboken) 2012;64:1787–1793. - PMC - PubMed
    1. Clinical and laboratory characteristics in juvenile-onset systemic lupus erythematosus across age groups. Massias JS, Smith EM, Al-Abadi E, et al. Lupus. 2020;29:474–481. - PMC - PubMed
    1. Clinical features, disease activity and outcomes of Malaysian children with paediatric systemic lupus erythematosus: a cohort from a tertiary centre. Lim SC, Chan EW, Tang SP. Lupus. 2020;29:1106–1114. - PubMed
    1. Initial presentation of childhood-onset systemic lupus erythematosus: a French multicenter study. Bader-Meunier B, Armengaud JB, Haddad E, et al. J Pediatr. 2005;146:648–653. - PubMed

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