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. 2023 Oct 17;7(1):1127-1132.
doi: 10.3233/ADR-230078. eCollection 2023.

Self-Reported Neurological Symptoms Two Years After Hospital Discharge Among COVID-19 Survivors

Jing-Juan Wang  1 , Qiao-Feng Zhang  1 , Di Liu  1 , Qing Du  2 , Cheng Xu  3 , Quan-Xin Wu  4 , Yi Tang  1 , Wang-Sheng Jin  1
Affiliations

Self-Reported Neurological Symptoms Two Years After Hospital Discharge Among COVID-19 Survivors

Jing-Juan Wang et al. J Alzheimers Dis Rep. .

Abstract

Background: The acute stage of COVID-19 often presents with neurological manifestations.

Objective: This study aims to investigate the long-term neurological effects on survivors.

Methods: This study recruited 1,546 COVID-19 survivors from Wuhan, including 1,119 nonsevere cases and 427 severe survivors. Participants were interviewed two years after discharge to report their neurological symptoms. The neurological symptoms of COVID-19 were compared between survivors of severe and nonsevere COVID-19.

Results: Among the 1,546 COVID-19 survivors, 44.24% discovered at least one neurological symptom. The most prevalent self-reported symptom was fatigue (28.33%), memory deficit (13.26%), attention deficit (9.96%), myalgia (8.34%), dizziness (3.82%), and headache (2.52%). Severe cases had higher incidences of fatigue, myalgia, memory deficit, attention deficit than nonsevere cases. Older age, severe COVID-19, and comorbidity burden were associated with long-term neurological symptoms.

Conclusion: Neurological symptoms are common among COVID-19 survivors, especially in severe cases.

Keywords: COVID-19; long-COVID; neurological symptoms; sequelae.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflict of interest to report.

References

    1. Luckhaupt SE, Horter L, Groenewold MR, de Perio MA, Robbins CL, Sweeney MH, Thomas I, Valencia D, Ingram A, Heinzerling A, Nguyen A, Townsend EB, Weber RC, Reichbind D, Dishman H, Kerins JL, Lendacki FR, Austin C, Dixon L, Spillman B, Simonson S, Tonzel J, Krueger A, Duwell M, Bachaus B, Rust B, Barrett C, Morrison B, Owers Bonner KA, Karlsson ND, Angelon-Gaetz K, McClure ES, Kline KE, Dangar D, Reed C, Karpowicz J, Anderson SM, Cantor S, Chaudhary I, Ellis EM, Taylor ML, Sedon A, Kocharian A, Morris C, Samson ME, Mangla AT (2023) COVID-19 outbreaks linked to workplaces, 23 US jurisdictions, August-October 2021. Public Health Rep 138, 333–340. - PMC - PubMed
    1. Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, Miao X, Li Y, Hu B (2020) Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 77, 683–690. - PMC - PubMed
    1. Herman E, Shih E, Cheng A (2022) Long COVID: Rapid evidence review. . Am Fam Physician. 106, 523–532. - PubMed
    1. Shaheen N, Shaheen A (2022) Long-term sequelae of COVID-19 (myalgic encephalomyelitis): An international cross-sectional study. Medicine (Baltimore) 101, e31819. - PMC - PubMed
    1. Jiang L, Liu X, Yan X, Liu Y, Wang Y, Yang Y, Wang L (2022) One-year self-reported neurological sequelae in older COVID-19 survivors. Ageing Neur Dis. 2, 10.

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