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. 2023 Nov 20;84(4):e144-e145.
doi: 10.1055/a-2192-5775. eCollection 2023 Oct.

Proton Therapy for Skull Base Chondrosarcoma

Dennis M Tang  1 , Raffaello M Cutri  1 , Arthur W Wu  1 , Chirag Patil  2 , Zachary S Zumsteg  3
Affiliations

Proton Therapy for Skull Base Chondrosarcoma

Dennis M Tang et al. J Neurol Surg Rep. .

Abstract

Chondrosarcoma is a type of an endochondral bone malignancy that is primarily treated surgically with radiation therapy used in the adjuvant setting or in cases of unresectable disease. Proton therapy has potential advantages compared with traditional photon therapy for the treatment of tumors in close proximity to critical structures due to the theoretic lower exit dose. Studies have shown improved survival in patients with skull base chondrosarcoma who undergo proton therapy. However, there is a lack of randomized data. Further studies are needed to define the role of proton therapy in the treatment of skull base chondrosarcoma.

Keywords: chondrosarcoma; proton therapy; radiation therapy; skull base.

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Conflict of interest statement

Conflict of Interest D.M.T. is a consultant for Acclarent, Inc. and 3-D Matrix. A.W.W. is a consultant for 3-D Matrix.

References

    1. Noel G, Gondi V. Proton therapy for tumors of the base of the skull. Chin Clin Oncol. 2016;5(04):51. - PubMed
    1. Amichetti M, Amelio D, Cianchetti M, Enrici R M, Minniti G. A systematic review of proton therapy in the treatment of chondrosarcoma of the skull base. Neurosurg Rev. 2010;33(02):155–165. - PubMed
    1. Simon F, Feuvret L, Bresson D et al.Surgery and proton therapy in Grade I and II skull base chondrosarcoma: a comparative retrospective study. PLoS One. 2018;13(12):e0208786. - PMC - PubMed
    1. Hasegawa H, Vakharia K, Graffeo C S et al.Long-term outcomes of grade I/II skull base chondrosarcoma: an insight into the role of surgery and upfront radiotherapy. J Neurooncol. 2021;153(02):273–281. - PubMed
    1. Palmisciano P, Haider A S, Sabahi M et al.Primary skull base chondrosarcomas: a systematic review. Cancers (Basel) 2021;13(23):5960. - PMC - PubMed