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. 2023 Nov 9:14:1255158.
doi: 10.3389/fphar.2023.1255158. eCollection 2023.

Bibliometric and visual analysis of doxorubicin-induced cardiotoxicity

Xiaoxiao Lin  1 , Guomin Wu  1 , Shuai Wang  1 , Jinyu Huang  1
Affiliations

Bibliometric and visual analysis of doxorubicin-induced cardiotoxicity

Xiaoxiao Lin et al. Front Pharmacol. .

Abstract

Background: Doxorubicin-induced cardiotoxicity represents a prevalent adverse effect encountered in patients undergoing treatment with doxorubicin. To date, there has been no bibliometric study to summarize the field of doxorubicin-induced cardiotoxicity. In our study, we aim to determine the current status and frontiers of doxorubicin-induced cardiotoxicity by bibliometric analysis. Methods: The documents concerning doxorubicin-induced cardiotoxicity are obtained from the Web of Science Core Collection database (WOSCC), and VOSviewer 1.6.16, CiteSpace 5.1.3 and the WOSCC's literature analysis wire were used to conduct the bibliometric analysis. Results: In total, 7,021 publications were encompassed, which are produced by 37,152 authors and 6,659 organizations, 1,323 journals, and 101 countries/regions. The most productive author, institution, country and journal were Bonnie Ky with 35 publications, University of Texas with 190 documents, the United States with 1,912 publications, and PLOS ONE with 120 documents. The first high-cited article was published in the NEJM with 8,134 citations authored by DJ Slamon et al., in 2001. For keyword analysis, there are four clusters depicted in distinct directions. The keywords in the red cluster are oxidative stress, apoptosis, and cardiomyopathy. The keywords in the green cluster are cardiotoxicity, heart failure, and anthracycline. The keywords in the blue cluster are chemotherapy, trastuzumab, and paclitaxel. The keywords in the purple cluster are doxorubicin, adriamycin, and cancer. Most of the documents were derived from the United States, China and Italy (4,080/7,021, 58.1%). The number of studies from other countries should be increased. Conclusion: In conclusion, the main research hotspots and frontiers in the field of doxorubicin-induced cardiotoxicity include the role of doxorubicin in cardiotoxicity, the mechanisms underlying doxorubicin-induced cardiotoxicity, and the development of treatment strategies for doxorubicin-induced cardiotoxicity. More studies are needed to explore the mechanisms and treatment of doxorubicin-induced cardiotoxicity.

Keywords: bibliometric analysis; develop; doxorubicin-induced cardiotoxicity; mechanisms; treatment.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Flowchart of the inclusion and exclusion criteria.
FIGURE 2
FIGURE 2
The yearly quantity and literature type of publications on TRE from inception to 1 May 2022. The figure includes (A) literature types distribution, (B) subject categories distribution, and (C) annual publications quantitative distribution.
FIGURE 3
FIGURE 3
The visualization knowledge maps of co-authorship. It includes (A) the co-authorship map of authors that indicates the authors who cooperate in the field of TRE, (B) the co-authorship map of organizations, and (C) the co-authorship map of countries. Different colors indicate different clusters, and the size of nodes indicates the number of publications. The thickness of the lines represents the link strength of the countries.
FIGURE 4
FIGURE 4
The visualization knowledge maps of citation, including (A) citation of Journal and (B) citation of documents. Different colors indicate different clusters, and the size of the nodes represents the counts of citations. The distance between the two nodes indicates their correlation.
FIGURE 5
FIGURE 5
The visualization of co-citation reference.
FIGURE 6
FIGURE 6
The visualization of keyword co-occurrence analysis. The size of nodes indicates the frequency of occurrences of the keywords, and the lines between the nodes represent their co-occurrence in the same publication. The shorter the distance between two nodes, the larger the number of the co-occurrence of the two keywords.
FIGURE 7
FIGURE 7
The burst detection analysis for twenty prominent words from 2010.
FIGURE 8
FIGURE 8
Main mechanisms of Doxorubicin-induced cardiotoxicity.
See this image and copyright information in PMC

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