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Editorial
. 2024 Jan 15;209(2):124-126.
doi: 10.1164/rccm.202311-2039ED.

Respiratory Metagenomics: Ready for Prime Time?

Emily Lydon  1 , Charles R Langelier  1   2
Affiliations
Editorial

Respiratory Metagenomics: Ready for Prime Time?

Emily Lydon et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Clinical implementation of respiratory metagenomics. Nanopore respiratory metagenomics were performed on BAL fluid, tracheal aspirates, and pleural fluid samples from intubated patients in the ICU with suspected respiratory infection. Routine clinical testing with culture was simultaneously performed. Sequencing reports were generated after 30 minutes and 2 hours for microbes and resistance mutations, respectively. Median turnaround time from sample acquisition to the reporting of results to clinicians was 6.7 hours. In comparison, preliminary culture results were reported after an average of 29 hours and were finalized in 40 hours. The impacts on clinical care, antibiotic agent prescribing, and infection control involvement were evaluated. AMR = antimicrobial resistance; BAL = bronchoalveolar lavage; ICU = intensive care unit.
See this image and copyright information in PMC

Comment on

  • Routine Metagenomics Service for ICU Patients with Respiratory Infection.
    Charalampous T, Alcolea-Medina A, Snell LB, Alder C, Tan M, Williams TGS, Al-Yaakoubi N, Humayun G, Meadows CIS, Wyncoll DLA, Paul R, Hemsley CJ, Jeyaratnam D, Newsholme W, Goldenberg S, Patel A, Tucker F, Nebbia G, Wilks M, Chand M, Cliff PR, Batra R, O'Grady J, Barrett NA, Edgeworth JD. Charalampous T, et al. Am J Respir Crit Care Med. 2024 Jan 15;209(2):164-174. doi: 10.1164/rccm.202305-0901OC. Am J Respir Crit Care Med. 2024. PMID: 37938162 Free PMC article.

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